2,3-Dimethoxyphenethylamine

Base Information

• Chemical Name: 2,3-Dimethoxyphenethylamine
• CAS No.: 3213-29-4
• Molecular Formula: C10H15NO2
• Molecular Weight: 181.235
• Hs Code.: 29214990
• European Community (EC) Number: 625-549-9
• UNII: LUW5Z6DJ9Q
• DSSTox Substance ID: DTXSID10185913
• Nikkaji Number: J579.370J
• Wikidata: Q72468196
• Mol file: 3213-29-4.mol

Synonyms:2,3-Dimethoxyphenethylamine;3213-29-4;2-(2,3-Dimethoxyphenyl)ethanamine;2-(2,3-dimethoxyphenyl)ethan-1-amine;Benzeneethanamine, 2,3-dimethoxy-;LUW5Z6DJ9Q;2,3-Dimethoxybenzeneethanamine;UNII-LUW5Z6DJ9Q;dimethoxybenzeneethan-amine;2,3-dimethoxy phenethylamine;SCHEMBL151944;DTXSID10185913;(2,3-dimethoxy-benzyl)methylamine;2,3-Dimethoxyphenethylamine, 97%;(2,3-dimethoxy-benzyl)methyl-amine;2-(2,3-Dimethoxyphenyl)-ethylamine;MFCD00060613;2-(2,3-dimethoxy-phenyl)-ethylamine;2-(2,3-Dimethoxyphenyl)ethanamine #;AKOS000162379;CS-0104581;FT-0634723;EN300-45045;D87831;A821161;J-507029

Chemical Property of 2,3-Dimethoxyphenethylamine

Chemical Property:

• Vapor Pressure: 0.00829mmHg at 25°C
• Refractive Index: n20/D 1.5320(lit.)
• Boiling Point: 267.2 °C at 760 mmHg
• Flash Point: 124.9 °C
• PSA: 44.48000
• Density: 1.041 g/cm³
• LogP: 1.90530
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 181.110278721
• Heavy Atom Count: 13
• Complexity: 141

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,3-dimethoxyphenethylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: COC1=CC=CC(=C1OC)CCN
• Uses: 2,3-Dimethoxyphenethylamine may be used in the synthesis of N-(2,3-dimethoxyphenethyl)-2-(3,4-dimethoxyphenyl)acetamide and N-(3,4-dimethoxyphenethyl)-phenyl acetamide.

Technology Process of 2,3-Dimethoxyphenethylamine

There total 15 articles about 2,3-Dimethoxyphenethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,3-dimethyoxybenzaldehyde (86-51-1) → 2,3-dimethoxyphenethylamine (3213-29-4)

Guidance literature:

Multi-step reaction with 4 steps

1: H₂, FeCl₃ / PtO₂ / ethanol

2: SOCl₂

3: H₂O

4: LiAlH₄

With lithium aluminium tetrahydride; thionyl chloride; hydrogen; iron(III) chloride; platinum(IV) oxide; In ethanol; water;

DOI:10.1021/ja01076a043

Reference yield:

2,3-dimethoxynitrostyrene (2815-67-0) → 2,3-dimethoxyphenethylamine (3213-29-4)

Guidance literature:

With hydrogenchloride; amalgamated zinc;

DOI:10.1080/10473289.2000.10464134

Reference yield:

2,3-dimethoxybenzyl alcohol (5653-67-8) → 2,3-dimethoxyphenethylamine (3213-29-4)

Guidance literature:

Multi-step reaction with 3 steps

1: SOCl₂

2: H₂O

3: LiAlH₄

With lithium aluminium tetrahydride; thionyl chloride; In water;

DOI:10.1021/ja01076a043

upstream raw materials:

2-(2,3-dimethoxyphenyl)acetonitrile

2,3-dimethoxynitrostyrene

(2,3-dimethoxy-phenyl)-acetic acid amide

(2,3-dimethoxy-phenyl)-acetaldehyde-oxime

Downstream raw materials:

(2,3-dimethoxy-phenethyl)-furfuryl-methyl-amine

piperonal-(2,3-dimethoxy-phenethylimine)

(2,3-dimethoxy-phenyl)-acetic acid-(2,3-dimethoxy-phenethylamide)

(2,3-dimethoxy-phenethyl)-urea

Refernces

• 1、 Pottie, Eline,Kupriyanova, Olga V.,Shevyrin, Vadim A.,Stove, Christophe P.. "Synthesis and Functional Characterization of 2-(2,5-Dimethoxyphenyl)-N-(2-fluorobenzyl)ethanamine (25H-NBF) Positional Isomers". . p. 1667 - 1673. Retrieved 2021/05/31.
• 2、 Vecchietti,Clarke,Colle,Dondio,Giardina,Petrone,Sbacchi. "Substituted 1-(aminomethyl)-2-(arylacetyl)-1,2,3,4- tetrahydroisoquinolines: A novel class of very potent antinociceptive agents with varying degrees of selectivity for κ and μ opioid receptors". . p. 2970 - 2978. Retrieved 2007/10/02.