5-Aminoquinoline

Base Information

• Chemical Name: 5-Aminoquinoline
• CAS No.: 146614-41-7
• Molecular Formula: C9H8N2
• Molecular Weight: 0
• Mol file: 146614-41-7.mol

Synonyms:5-AMINO-QUINOLINE, 98+%

Chemical Property of 5-Aminoquinoline

Chemical Property:

• Vapor Pressure: 0.000617mmHg at 25°C
• Melting Point: 106-109℃
• Refractive Index: 1.708
• Boiling Point: 310°C at 760 mmHg
• Flash Point: 171.5°C
• Density: 1.21g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s): R36/38:
• Hazard Codes: Xi:Irritant
• Statements: R36/38:
• Safety Statements: S26:; S36:

MSDS Files:

Useful:

Technology Process of 5-Aminoquinoline

There total 34 articles about 5-Aminoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.2%

5-nitroquinoline (607-34-1) → 5-Aminoquinoline (611-34-7,146614-41-7)

Guidance literature:

With hydrazine hydrate; In ethanol; at 40 ℃; for 0.5h;

DOI:10.1039/c6gc03141b

Reference yield: 93.0%

→ 5-Aminoquinoline (611-34-7,146614-41-7)

Guidance literature:

With C₃₆H₅₆Cl₃CrN₂O; magnesium; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane; In tetrahydrofuran; at 40 ℃; for 24h;

Reference yield: 60.0%

5-quinolyl azide (20377-01-9) → 5-Aminoquinoline (611-34-7,146614-41-7)

Guidance literature:

With diethylamine; Ambient temperature; Irradiation;

upstream raw materials:

quinolin-5-ol

3-chloro-[5]quinolylamine

5-nitroquinoline

3-bromo-5-nitro-quinoline-1-oxide

Downstream raw materials:

thiazolo<4,5-f>quinolin-2-amine

5-acetylaminoquinoline

2-[5]quinolylamino-4-chloro-benzoic acid

5-(α-chloroacetylamino)quinoline

Refernces

• 1、 Huang, Haigen,Wang, Xueguang,Sheng, Yao,Chen, Chenju,Zou, Xiujing,Shang, Xingfu,Lu, Xionggang. "Nitrogen-doped graphene-activated metallic nanoparticle-incorporated ordered mesoporous carbon nanocomposites for the hydrogenation of nitroarenes". . p. 8898 - 8909. Retrieved 2018.
• 2、 El-Damasy, Ashraf Kareem,Cho, Nam-Chul,Pae, Ae Nim,Kim, Eunice Eunkyeong,Keum, Gyochang. "Novel 5-substituted-2-anilinoquinolines with 3-(morpholino or 4-methylpiperazin-1-yl)propoxy moiety as broad spectrum antiproliferative agents: Synthesis, cell based assays and kinase screening". . p. 3307 - 3312. Retrieved 2016.
• 3、 Takeshita, Mitsuhiro,Yoshida, Sachiko. "REDUCTION OF HETERO-AROMATIC NITRO COMPOUNDS WITH BAKER'S YEAST". . p. 2201 - 2204. Retrieved 1990.
• 4、 Weidner, John J.,Peet, Norton P.. "Direct Conversion of Hydroxy Aromatic Compounds to Heteroarylamines via a One-Pot Smiles Rearrangement Procedure". . p. 1857 - 1860. Retrieved 1997.
• 5、 Zhao, Lixing,Hu, Chenyang,Cong, Xuefeng,Deng, Gongda,Liu, Liu Leo,Luo, Meiming,Zeng, Xiaoming. "Cyclic (Alkyl)(amino)carbene Ligand-Promoted Nitro Deoxygenative Hydroboration with Chromium Catalysis: Scope, Mechanism, and Applications". supporting information. p. 1618 - 1629. Retrieved 2021/01/25.
• 6、 Bao, Lingxiang,Fei, Teng,Li, Jiazhe,Pang, Siping,Sun, Chenghui,Yan, Zhiyuan,Yu, Zongbao. "Palladium supported on metal–organic framework as a catalyst for the hydrogenation of nitroarenes under mild conditions". . . Retrieved 2020/03/24.