1,4-DIMETHYL-3,4-DIHYDRO-ISOQUINOLINE

Base Information

• Chemical Name: 1,4-DIMETHYL-3,4-DIHYDRO-ISOQUINOLINE
• CAS No.: 59261-37-9
• Molecular Formula: C11H13 N
• Molecular Weight: 159.231
• Hs Code.: 2933499090
• Mol file: 59261-37-9.mol

Synonyms:1,4-Dimethyl-3,4-dihydroisoquinoline;NSC 272275

Chemical Property of 1,4-DIMETHYL-3,4-DIHYDRO-ISOQUINOLINE

Chemical Property:

• Vapor Pressure: 0.171mmHg at 25°C
• Boiling Point: 220°C at 760 mmHg
• Flash Point: 78.4°C
• PSA: 12.36000
• Density: 1.02g/cm³
• LogP: 2.04830

Purity/Quality:

98.5% ^*data from raw suppliers

1,4-Dimethyl-3,4-dihydroisoquinoline 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,4-DIMETHYL-3,4-DIHYDRO-ISOQUINOLINE

There total 7 articles about 1,4-DIMETHYL-3,4-DIHYDRO-ISOQUINOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

[1-Phenyl-eth-(Z)-ylidene]-((E)-propenyl)-amine (87869-98-5) → 1,4-dimethyl-3,4-dihydroisoquinoline (59261-37-9)

Guidance literature:

at 600 ℃; under 0.1 Torr;

DOI:10.1021/jo00174a036

Reference yield:

N-acetyl-β-methylphenethylamine (22596-62-9) → 1,4-dimethyl-3,4-dihydroisoquinoline (59261-37-9)

Guidance literature:

With phosphorus pentoxide; xylene; trichlorophosphate;

Reference yield:

2-phenylpropylamine (582-22-9) → 1,4-dimethyl-3,4-dihydroisoquinoline (59261-37-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 160 °C

2: phosphorus (V)-oxide; tetralin

With tetralin; phosphorus pentoxide;

upstream raw materials:

N-acetyl-β-methylphenethylamine

[1-Phenyl-eth-(Z)-ylidene]-((E)-propenyl)-amine

tetralin

2-phenylpropylamine

Downstream raw materials:

1,4-Dimethyl-isochinolin

Refernces

• 1、 Agrawal,Mooney,Sartorelli. "Potential antitumor agents. 13. 4 Methyl 5 amino 1 formylisoquinoline thiosemicarbazone". . p. 970 - 972. Retrieved 2007/10/04.