7-Chloro-2-iodothieno[3,2-b]pyridine

Base Information

• Chemical Name: 7-Chloro-2-iodothieno[3,2-b]pyridine
• CAS No.: 602303-26-4
• Molecular Formula: C7H3ClINS
• Molecular Weight: 295.531
• Hs Code.: 2934999090
• European Community (EC) Number: 889-065-1
• DSSTox Substance ID: DTXSID00590491
• Nikkaji Number: J2.041.736F
• Wikidata: Q72452677
• Mol file: 602303-26-4.mol

Synonyms:7-Chloro-2-iodothieno[3,2-b]pyridine;602303-26-4;7-chloro-2-iodo-thieno[3,2-b]pyridine;THIENO[3,2-B]PYRIDINE, 7-CHLORO-2-IODO-;MFCD08448166;C7H3ClINS;2-Iodo-7-chlorothieno[3,2-b]pyridine;SCHEMBL108770;DTXSID00590491;GYHAKTKQWPBADS-UHFFFAOYSA-N;CS-D1056;AKOS015851081;AM81192;PB17532;AS-42150;SY034530;DB-014671;7-Chloro-2-iodothieno[3 pound not2-b]pyridine;EN300-7375297;A832646;J-519193

Chemical Property of 7-Chloro-2-iodothieno[3,2-b]pyridine

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.771
• Boiling Point: 341.701 ºC at 760 mmHg
• PKA: 2.18±0.40(Predicted)
• Flash Point: 160.455 ºC
• PSA: 41.13000
• Density: 2.107 g/cm³
• LogP: 3.55430
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 3.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 294.87195
• Heavy Atom Count: 11
• Complexity: 157

Purity/Quality:

98%,99%, ^*data from raw suppliers

7-Chloro-2-iodothieno[3,2-b]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CN=C2C=C(SC2=C1Cl)I

Technology Process of 7-Chloro-2-iodothieno[3,2-b]pyridine

There total 1 articles about 7-Chloro-2-iodothieno[3,2-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

7-chlorothieno[3,2-b]pyridine (69627-03-8) → 7-chloro-2-iodo-[3,2-b]thienopyridine (602303-26-4)

Guidance literature:

7-chlorothieno[3,2-b]pyridine; With n-butyllithium; In tetrahydrofuran; hexane; at -70 ℃; for 2h; Inert atmosphere; Large scale;

With iodine; In tetrahydrofuran; hexane; at -70 - 20 ℃; for 19.3h; Inert atmosphere; Large scale;

DOI:10.1021/op0340457

Reference yield: 74.0%

2-fluoro-4-nitrophenol (403-19-0) + 7-chloro-2-iodo-[3,2-b]thienopyridine (602303-26-4) → 7-(2-fluoro-4-nitrophenoxy)-2-iodothieno[3,2-b]pyridine (918643-33-1)

Guidance literature:

With potassium carbonate; In diphenylether; at 200 ℃; for 3h;

Reference yield: 72.0%

m-tolylboronic acid (17933-03-8) + 7-chloro-2-iodo-[3,2-b]thienopyridine (602303-26-4) → 7-chloro-2-(m-tolyl)thieno[3,2-b]pyridine

Guidance literature:

With palladium diacetate; caesium carbonate; triphenylphosphine; In toluene; for 24h; Reflux;

upstream raw materials:

7-chlorothieno[3,2-b]pyridine

Downstream raw materials:

3-Fluoro-4-(2-iodothieno[3,2-b]pyridin-7-yloxy)aniline

2-benzyl-5-(3-fluoro-4-(2-iodothieno[3,2-b]pyridin-7-yloxy)phenyl)pyrimidin-4(3H)-one

5-(3-fluoro-4-(2-iodothieno[3,2-b]pyridin-7-yloxy)phenyl)-3-methyl-2-(phenylamino)pyrimidin-4(3H)-one

5-(2,5-difluoro-4-(2-iodothieno[3,2-b]pyridin-7-yloxy)phenyl)-3-methyl-2-(phenylamino)pyrimidin-4(3H)-one

Refernces

• 1、 -. "NITROGEN-CONTAINING FUSED CYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF". . . Retrieved 2022/01/03.
• 2、 -. "Combination of mTOR inhibitors and P13-kinase inhibitors, and uses thereof". Page/Page column 361; 362. . Retrieved 2016/04/26.