OXAZOL-4-YL-METHYLAMINE HYDROCHLORIDE

Base Information

• Chemical Name: OXAZOL-4-YL-METHYLAMINE HYDROCHLORIDE
• CAS No.: 55242-82-5
• Molecular Formula: C4H6N2O
• Molecular Weight: 98.1044
• Hs Code.: 2934999090
• Mol file: 55242-82-5.mol

Synonyms:oxazol-4-ylmethanamine;(1,3-Oxazol-4-yl)methylamine;1,3-oxazol-4-ylmethylamine;4-(Aminomethyl)-1,3-oxazole;oxazol-4-ylmethanamine;

Chemical Property of OXAZOL-4-YL-METHYLAMINE HYDROCHLORIDE

Chemical Property:

• Vapor Pressure: 0.77mmHg at 25°C
• Refractive Index: 1.499
• Boiling Point: 183.45 °C at 760 mmHg
• PKA: 7.46±0.29(Predicted)
• Flash Point: 64.748 °C
• PSA: 52.05000
• Density: 1.148 g/cm³
• LogP: 0.83360
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

99%, ^*data from raw suppliers

Oxazol-4-yl-methylamine 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Oxazol-4-yl-methanamine is used as a reactant in the preparation of piperazin-1-yl-pyridazine-based selective stearoyl-CoA desaturase-1 inhibitors for the treatment of obesity and metabolic syndrome.

Technology Process of OXAZOL-4-YL-METHYLAMINE HYDROCHLORIDE

There total 1 articles about OXAZOL-4-YL-METHYLAMINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,3-oxazole-4-carbonitrile (55242-84-7) → C-oxazol-4-yl-methylamine (55242-82-5)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol; Ambient temperature;

DOI:10.1002/ardp.19753080113

Reference yield: 51.0%

C-oxazol-4-yl-methylamine (55242-82-5) + 2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methylthiazole-5-carboxylic acid (1072804-20-6) → 2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-(oxazol-4-ylmethyl)thiazole-5-carboxamide (1072804-39-7)

Guidance literature:

2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methylthiazole-5-carboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h;

C-oxazol-4-yl-methylamine; In N,N-dimethyl-formamide; at 20 ℃; for 17h;

DOI:10.1016/j.bmc.2014.12.014

Reference yield: 49.0%

C-oxazol-4-yl-methylamine (55242-82-5) + 2-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)isonicotinic acid (1202928-11-7) → 2-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)-N-(oxazol-4-ylmethyl)isonicotinamide (1202926-91-7)

Guidance literature:

2-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)isonicotinic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

C-oxazol-4-yl-methylamine; In N,N-dimethyl-formamide; at 20 ℃; for 17h;

upstream raw materials:

1,3-oxazole-4-carbonitrile

Downstream raw materials:

2-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)-N-(oxazol-4-ylmethyl)isonicotinamide

C₂₁H₁₉F₃N₆O₃

2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-(oxazol-4-ylmethyl)thiazole-5-carboxamide

Refernces