Ethanone, 2-chloro-1-(2-fluorophenyl)- (9CI)

Base Information

• Chemical Name: Ethanone, 2-chloro-1-(2-fluorophenyl)- (9CI)
• CAS No.: 53688-17-8
• Molecular Formula: C8H6ClFO
• Molecular Weight: 172.586
• Hs Code.: 2914700090
• Mol file: 53688-17-8.mol

Synonyms:Ethanone, 2-chloro-1-(2-fluorophenyl)- (9CI)

Chemical Property of Ethanone, 2-chloro-1-(2-fluorophenyl)- (9CI)

Chemical Property:

• Boiling Point: 234.0±15.0 °C(Predicted)
• PSA: 17.07000
• Density: 1.263±0.06 g/cm3(Predicted)
• LogP: 2.24720
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility.: Chloroform (Slightly), Methanol (Slightly), Dichloromethane

Purity/Quality:

99% ^*data from raw suppliers

2-FluorophenacylChloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Fluorophenacyl Chloride is 2-fluoro substituted α-chloro acetophenone used as a synthetic intermediate for neurologically active pharmaceutical compounds.

Technology Process of Ethanone, 2-chloro-1-(2-fluorophenyl)- (9CI)

There total 4 articles about Ethanone, 2-chloro-1-(2-fluorophenyl)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

2-fluorostyrene (394-46-7) → 2-chloro-1-(fluorophenyl)-ethanone (53688-17-8)

Guidance literature:

With tris(2,2'-bipyridyl)ruthenium dichloride; chloroform; [bis(acetoxy)iodo]benzene; In chloroform; at 20 ℃; for 12h; Irradiation;

DOI:10.1016/j.cclet.2020.02.022

Reference yield:

2'-Fluoroacetophenone (445-27-2) → 2-chloro-1-(fluorophenyl)-ethanone (53688-17-8)

Guidance literature:

With potassium peroxymonosulfate; ammonium chloride; In methanol; for 5h; Reflux;

DOI:10.1246/cl.2012.432

Reference yield:

2-bromo-2'-fluoroacetophenone (655-15-2) → 2-chloro-1-(fluorophenyl)-ethanone (53688-17-8)

Guidance literature:

With N-benzyl-N,N,N-triethylammonium chloride; benzenesulfonyl chloride; In water; at 20 ℃; for 3h; Solvent; Green chemistry;

DOI:10.1039/c6ra00433d

upstream raw materials:

methanol

2'-Fluoroacetophenone

2-bromo-2'-fluoroacetophenone

2-fluorostyrene

Downstream raw materials:

6-chloro-2-(2-fluoro-phenyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]thiazin-2-ol

6-chloro-2-(2-fluoro-phenyl)-3H-pyrido[2,3-b][1,4]thiazine

2-(2-fluorophenyl)-2-phenyloxirane

2'-Fluoroacetophenone

Refernces

• 1、 Yin, Congcong,Wu, Weilong,Hu, Yang,Tan, Xuefeng,You, Cai,Liu, Yuanhua,Chen, Ziyi,Dong, Xiu-Qin,Zhang, Xumu. "Iridium-Catalyzed Asymmetric Hydrogenation of Halogenated Ketones for the Efficient Construction of Chiral Halohydrins". supporting information. p. 2119 - 2124. Retrieved 2018/04/30.
• 2、 Swamy, Peraka,Kumar, MacHarla Arun,Reddy, Marri Mahender,Narender, Nama. "Mild and efficient α-chlorination of carbonyl compounds using ammonium chloride and oxone (2KHSO5·KHSO4· K2SO4)". supporting information; experimental part. p. 432 - 434. Retrieved 2012/06/01.