(+)-N-Methylpseudoephedrine

Base Information Edit

Chemical Name:(+)-N-Methylpseudoephedrine
CAS No.:51018-28-1
Molecular Formula:C₁₁H₁₇NO
Molecular Weight:179.262
Hs Code.:
European Community (EC) Number:625-975-5
UNII:6P8GZM6LZU
DSSTox Substance ID:DTXSID401021166
Nikkaji Number:J308.212A
Wikipedia:N-Methylpseudoephedrine
Wikidata:Q6951379
Mol file:51018-28-1.mol

Synonyms:methylephedrine;methylpseudoephedrine;N-methylephedrine;N-methylephedrine hydrochloride, (R*,R*)-(+-)-isomer;N-methylephedrine hydrochloride, (R*,S*)-(+-)-isomer;N-methylephedrine hydrochloride, (R*,S*)-isomer;N-methylephedrine hydrochloride, (R-(R*,S*))-isomer;N-methylephedrine hydrochloride, (S-(R*,R*))-isomer;N-methylephedrine, (R*,R*)-isomer;N-methylephedrine, (R*,S*)-(+-)-isomer;N-methylephedrine, (R*,S*)-isomer;N-methylephedrine, (R-(R*,S*))-isomer;N-methylephedrine, (S-(R*,R*))-isomer

This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of (+)-N-Methylpseudoephedrine Edit

Chemical Property:

Vapor Pressure:0.0108mmHg at 25°C
Melting Point:29-31 °C(lit.)
Refractive Index:1.53
Boiling Point:145 °C24 mm Hg(lit.)
PKA:13.88±0.20(Predicted)
Flash Point:96.9°C
PSA：23.47000
Density:1.009g/cm³
LogP:1.67010
Storage Temp.:2-8°C
Solubility.:Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
XLogP3:1.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:179.131014166
Heavy Atom Count:13
Complexity:141

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:Xn
Statements: 20/21/22-36/37/38
Safety Statements: 26-36

MSDS Files:

Useful:

Canonical SMILES:CC(C(C1=CC=CC=C1)O)N(C)C
Isomeric SMILES:C[C@@H]([C@H](C1=CC=CC=C1)O)N(C)C
Uses N-Methylpseudoephedrine is a N-methylated analogue of the non-selective adrenergic agonist Pseudoephedrine (P839350). N-Methylpseudoephedrine is an alkaloid from Ephedra species widely used in Chinese medicine.

Technology Process of (+)-N-Methylpseudoephedrine

There total 20 articles about (+)-N-Methylpseudoephedrine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 16251-47-1
(4S,5S)-3,4-dimethyl-5-phenyl-1,3-oxazolidin-2-one

: 1201-56-5,14222-20-9,17605-71-9,39263-91-7,42151-56-4,51018-28-1,62560-55-8,87040-40-2,552-79-4
(1S,2S)-N-Methylpseudoephedrine

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran;
DOI:10.1016/S0040-4039(00)01753-6

Reference yield: 99.0%

: 15351-09-4
metamfepramone

: 1201-56-5,14222-20-9,17605-71-9,39263-91-7,42151-56-4,51018-28-1,62560-55-8,87040-40-2,552-79-4
(1S,2S)-N-Methylpseudoephedrine

Guidance literature:: With bis(1,5-cyclooctadiene)diiridium(I) dichloride; f-amphox; hydrogen; caesium carbonate; In isopropyl alcohol; at 20 - 30 ℃; for 12h; under 15201 Torr; stereoselective reaction; Catalytic behavior; Inert atmosphere; Autoclave;
DOI:10.1021/acs.orglett.7b00844