2-chloro-N-(4-phenyl-1,3-thiazol-2-yl)acetamide

Base Information

• Chemical Name: 2-chloro-N-(4-phenyl-1,3-thiazol-2-yl)acetamide
• CAS No.: 5039-16-7
• Molecular Formula: C11H9ClN2OS
• Molecular Weight: 252.724
• Hs Code.: 2934100090
• DSSTox Substance ID: DTXSID40381805
• Wikidata: Q82172878
• Mol file: 5039-16-7.mol

Synonyms:2-chloro-N-(4-phenyl-1,3-thiazol-2-yl)acetamide;5039-16-7;2-Chloro-N-(4-phenyl-thiazol-2-yl)-acetamide;MFCD00124517;SCHEMBL1357607;DTXSID40381805;STK034390;AKOS000266784;5K-599S;2-Chloro-N-(4-phenylthiazol-2-yl)acetamide;BB 0217361;CS-0307536;N-(4-phenyl-2-thiazolyl)-2-chloroacetamide;2-chloro-N-(4-phenylthiazol-2-yl) acetamide;EN300-01733;AF-407/02986041;SR-01000363757;N1-(4-phenyl-1,3-thiazol-2-yl)-2-chloroacetamide;SR-01000363757-1;Z56827156;n1-(4-phenyl-1,3-thiazol-2-yl)-2-chloroacetamide, AldrichCPR

Chemical Property of 2-chloro-N-(4-phenyl-1,3-thiazol-2-yl)acetamide

Chemical Property:

• PSA: 70.23000
• LogP: 3.06040
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 252.0124118
• Heavy Atom Count: 16
• Complexity: 246

Purity/Quality:

98%min ^*data from raw suppliers

2-Chloro-N-(4-phenyl-1,3-thiazol-2-yl)acetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=CSC(=N2)NC(=O)CCl

Technology Process of 2-chloro-N-(4-phenyl-1,3-thiazol-2-yl)acetamide

There total 7 articles about 2-chloro-N-(4-phenyl-1,3-thiazol-2-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-Amino-4-phenylthiazole (2010-06-2) + chloroacetyl chloride (79-04-9) → 2-chloro-N-(phenylthiazol-2-yl)acetamide (5039-16-7)

Guidance literature:

chloroacetyl chloride; With triethylamine; In tetrahydrofuran; at 0 ℃; for 0.25h; Inert atmosphere;

2-Amino-4-phenylthiazole; In tetrahydrofuran; at 0 - 20 ℃; for 13h;

DOI:10.1016/j.tetlet.2016.01.079

Reference yield: 95.0%

→ 2-chloro-N-(phenylthiazol-2-yl)acetamide (5039-16-7)

Guidance literature:

Reference yield:

acetophenone (98-86-2) → 2-chloro-N-(phenylthiazol-2-yl)acetamide (5039-16-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / bromine / Heating

2: glacial acetic acid; sodium acetate / 6 h / Heating

With bromine; sodium acetate; acetic acid;

upstream raw materials:

2-Amino-4-phenylthiazole

chloroacetyl chloride

acetophenone

α-bromoacetophenone

Downstream raw materials:

4-phenyl-2-(N-piperidinoacetamido)thiazole

4-phenyl-2-(N-morpholinoacetamido)thiazole

N,N'-bis-(4-phenyl-thiazol-2-yl)-2,2'-piperazine-1,4-diyl-bis-acetamide

4-Phenyl-2-<α-(benzimidazol-1-yl)-acetamino>-thiazol

Refernces

• 1、 El-Dash, Yara,Elzayat, Emad,Abdou, Amr M.,Hassan, Rasha A.. "Novel thienopyrimidine-aminothiazole hybrids: Design, synthesis, antimicrobial screening, anticancer activity, effects on cell cycle profile, caspase-3 mediated apoptosis and VEGFR-2 inhibition". . . Retrieved 2021/07/10.
• 2、 -. "Β - secretase enzyme has the function of inhibiting compound, the preparation of the compounds and use thereof". Paragraph 0115; 0116. . Retrieved 2018/03/26.