2 4-DIMETHOXY-5-METHYLPYRIMIDINE 97

Base Information

• Chemical Name: 2 4-DIMETHOXY-5-METHYLPYRIMIDINE 97
• CAS No.: 5151-34-8
• Molecular Formula: C7H10N2O2
• Molecular Weight: 154.169
• Mol file: 5151-34-8.mol

Synonyms:2 4-DIMETHOXY-5-METHYLPYRIMIDINE 97;2,4-Dimethoxy-5-methylpyridine

Chemical Property of 2 4-DIMETHOXY-5-METHYLPYRIMIDINE 97

Chemical Property:

• Melting Point: 58-62 °C(lit.)
• Storage Temp.: 2-8°C
• Sensitive.: Air Sensitive

Purity/Quality:

99% ^*data from raw suppliers

2,4-Dimethoxy-5-methylpyrimidine 95+% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22-41-43
• Safety Statements: 37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2 4-DIMETHOXY-5-METHYLPYRIMIDINE 97

There total 8 articles about 2 4-DIMETHOXY-5-METHYLPYRIMIDINE 97 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

5-bromo-2,4-dimethoxypyrimidine (56686-16-9) + methyl iodide (74-88-4) → 2,4-Dimethoxy-5-methylpyrimidine (5151-34-8)

Guidance literature:

5-bromo-2,4-dimethoxypyrimidine; With TurboGrignard; In tetrahydrofuran; at -20 ℃; for 2h; Inert atmosphere;

With copper(I) cyanide*2 lithium chloride; In tetrahydrofuran; at -30 ℃;

methyl iodide; In tetrahydrofuran; at 20 ℃; Cooling;

DOI:10.1021/ol800353s

Reference yield: 86.0%

thymin (65-71-4,28806-14-6,691841-57-3) → 2,4-Dimethoxy-5-methylpyrimidine (5151-34-8)

Guidance literature:

DOI:10.1248/cpb.36.2673

Reference yield: 62.0%

2,4-dimethoxypyrimidine (3551-55-1) + methyl iodide (74-88-4) → 2,4-Dimethoxy-5-methylpyrimidine (5151-34-8)

Guidance literature:

2,4-dimethoxypyrimidine; With n-butyllithium; CuCl₂*TMEDA; 2,2,6,6-tetramethylpiperidinyl-lithium; In tetrahydrofuran; hexanes; at 20 ℃; for 2h; Inert atmosphere;

methyl iodide; In tetrahydrofuran; hexanes; at 0 - 30 ℃; for 16h; Inert atmosphere;

DOI:10.1002/chem.201100990

upstream raw materials:

2,6-dichloro-5-methylpyrimidine

sodium methylate

5-methyl-6-chloro-2,4-dimethoxypyrimidine

2,4-dimethoxypyrimidine

Downstream raw materials:

1-methylthymine

5-methyl-1-(2'-O-p-tolylsulfonylethoxymethyl)uracil

1-[(2-hydroxyethoxy)methyl]thymine

5-methylcytidine

Refernces

• 1、 Nguyen, Tan Tai,Chevallier, Floris,Jouikov, Viatcheslav,Mongin, Florence. "New Gilman-type lithium cuprate from a copper(II) salt: synthesis and deprotonative cupration of aromatics". experimental part. p. 6787 - 6790. Retrieved 2010/04/29.
• 2、 Gambacorta, Augusto,Tofani, Daniela,Loreto, Maria Antonietta,Gasperi, Tecla,Bernini, Roberta. "HSAB-driven chemoselective N1-alkylation of pyrimidine bases and their 4-methoxy- or 4-acetylamino-derivatives". . p. 6848 - 6854. Retrieved 2007/10/03.