1-Phenyl-2-(pyrrolidin-1-yl)propan-1-ol

Base Information

• Chemical Name: 1-Phenyl-2-(pyrrolidin-1-yl)propan-1-ol
• CAS No.: 56571-91-6
• Molecular Formula: C₁₃H₁₉NO
• Molecular Weight: 205.3
• European Community (EC) Number: 626-192-1
• DSSTox Substance ID: DTXSID501344517
• Mol file: 56571-91-6.mol

Synonyms:1-phenyl-2-(pyrrolidin-1-yl)propan-1-ol;(1S,2R)-1-Phenyl-2-(1-pyrrolidinyl)-1-propanol;56571-91-6;173676-57-8;MFCD01632702;(1R,2S)-N,N-Tetramethylenenorephedrine;56571-92-7;SCHEMBL2714074;FZVHJGJBJLFWEX-UHFFFAOYSA-N;DTXSID501344517;(1S,2R)-1-Phenyl-2-pyrrolidin-1-yl-propan-1-olhydrochloride;AKOS009159507;AB10789;SB45457;SY044686;beta-methyl-alpha-phenyl-1-pyrrolidineethanol;FT-0652960;FT-0773239;EN300-717675

Chemical Property of 1-Phenyl-2-(pyrrolidin-1-yl)propan-1-ol

Chemical Property:

• Melting Point: 43-47 °C(lit.)
• Refractive Index: 1.562
• Boiling Point: 321.3°Cat760mmHg
• Flash Point: 148.1°C
• PSA: 23.47000
• Density: 1.075g/cm³
• LogP: 2.14220
• Storage Temp.: 2-8°C
• XLogP3: 2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 205.146664230
• Heavy Atom Count: 15
• Complexity: 183

Purity/Quality:

98%,99%, ^*data from raw suppliers

(1S,2R)-1-Phenyl-2-(1-pyrrolidinyl)-1-propanol 98% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C(C1=CC=CC=C1)O)N2CCCC2
• Uses: (1S,2R)-1-Phenyl-2-(1-pyrrolidinyl)-1-propanol can be used as: A chiral catalyst to prepare corresponding enantioselective secondary aromatic alcohols by the addition of dialkylzincs to aromatic aldehydes. A reactant to synthesize optically active (R)-(+)-1-phenyl-2-(1-pyrrolidinyl)-1-propanone by oxidation reaction.

Technology Process of 1-Phenyl-2-(pyrrolidin-1-yl)propan-1-ol

There total 49 articles about 1-Phenyl-2-(pyrrolidin-1-yl)propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(1R,2S)-(+)-1-phenyl-2-(1-pyrrolidinyl)-1-propanol hydrochloride (210558-66-0) → (1R,2S)-1-phenyl-2-(1-pyrrolidinyl)-1-propanol (56571-91-6,56571-92-7,123620-80-4,127641-25-2)

Guidance literature:

With hydrogenchloride; In water; toluene; Reflux;

Reference yield: 99.0%

(1R,2S)-1-phenyl-2-(pyrrolidin-1-yl)propan-1-ol D-tartrate → (1R,2S)-1-phenyl-2-(1-pyrrolidinyl)-1-propanol (56571-91-6,56571-92-7,123620-80-4,127641-25-2)

Guidance literature:

With hydrogenchloride; In water; toluene;

Reference yield: 99.0%

1,4-dibromo-butane (110-52-1) + (1R,2S)-norephedrine (492-41-1,58550-13-3,757124-50-8) → (1R,2S)-1-phenyl-2-(1-pyrrolidinyl)-1-propanol (56571-91-6,56571-92-7,123620-80-4,127641-25-2)

Guidance literature:

With potassium carbonate; In acetonitrile; for 24h; Heating;

DOI:10.1002/chem.200601347

upstream raw materials:

1,4-Diiodobutane

(1S,2R)-(+)-norphedrine

1,4-dibromo-butane

(SR)-(+/-)-1-phenyl-2-(1-pyrrolidinyl)-1-propanone

Downstream raw materials:

(1R,2S)-1-phenyl-2-pyrrolidinylpropanamine

(2S,3R,7aR)-3-methyl-2-phenylhexahydropyrrolo[2.1-b]oxazole

(2S)-2-(2-amino-5-chlorophenyl)-4-cyclopropyl-1,1,1-trifluorobut-3-yn-2-ol

(1R,2S)-1-phenyl-2-(pyrrolidin-1-yl)propyl (2S)-5-[(tert-butoxycarbonyl)amino]-2-(4,5-dihydroimidazo[1,5-a]quinolin-3-ylmethyl)pentanoate

Refernces

• 1、 -. "Synthesis method of chiral compound". Paragraph 0169-0170. . Retrieved 2020/01/25.
• 2、 -. "Method for preparing chiral (1R,2S)-1-phenyl-2-(1-pyrrolidyl)propane-1-alcohol". Paragraph 0043-0051. . Retrieved 2019/01/23.