5-Fluoro-1H-indene

Base Information

• Chemical Name: 5-Fluoro-1H-indene
• CAS No.: 52031-15-9
• Molecular Formula: C9H7F
• Molecular Weight: 134.153
• Hs Code.: 2903999090
• DSSTox Substance ID: DTXSID40505347
• Wikidata: Q82360391
• Mol file: 52031-15-9.mol

Synonyms:5-FLUORO-1H-INDENE;52031-15-9;1H-Indene, 5-fluoro-;5-fluoro-indene;SCHEMBL819543;DTXSID40505347;DUAUUKDYIHSGFG-UHFFFAOYSA-N;AKOS005137903;DS-3329;FT-0692722;N14223;EN300-1613354;A1-21339;J-517492;(2-OXO-1,3-BENZOXAZOL-3(2H)-YL)ACETICACID

Chemical Property of 5-Fluoro-1H-indene

Chemical Property:

• Vapor Pressure: 0.936mmHg at 25°C
• Refractive Index: 1.569
• Boiling Point: 185.9°C at 760 mmHg
• Flash Point: 58.1°C
• PSA: 0.00000
• Density: 1.156g/cm³
• LogP: 2.39500
• XLogP3: 3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 134.053178385
• Heavy Atom Count: 10
• Complexity: 151

Purity/Quality:

99.99%HPLC ^*data from raw suppliers

5-Fluoro-1H-indene 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1C=CC2=C1C=CC(=C2)F

Technology Process of 5-Fluoro-1H-indene

There total 7 articles about 5-Fluoro-1H-indene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-fluoro-2,3-dihydro-1H-inden-1-ol (52085-94-6) → 5-fluoro-1H-indene (52031-15-9)

Guidance literature:

With magnesium sulfate; Heating;

Reference yield:

5-fluoro-2,3-dihydro-1H-inden-1-ol (52085-92-4) → 5-fluoro-1H-indene (52031-15-9)

Guidance literature:

With toluene-4-sulfonic acid; In toluene; for 3h; Dean-Stark; Reflux;

Reference yield:

6-fluoroindan-1-one (1481-32-9) → 5-fluoro-1H-indene (52031-15-9)

Guidance literature:

Multi-step reaction with 2 steps

1: LiAlH₄ / diethyl ether

2: MgSO₄ / Heating

With lithium aluminium tetrahydride; magnesium sulfate; In diethyl ether;

upstream raw materials:

6-fluoro-2,3-dihydro-1H-inden-1-ol

4-fluorocinnamic acid

6-fluoroindan-1-one

3-(4-fluorophenyl)propanoic acid

Downstream raw materials:

C₉H₇FO

3-amino-4-fluoro-N-((1R,2S)-5-fluoro-2-hydroxy-2,3-dihydro-1H-inden-1-yl)benzamide

7-fluoroisoquinoline

rac-cis-(1a,6a)-3-fluoro-6,6a-dihydro-1aH-1-oxacyclopropa[a]indene

Refernces

• 1、 Pearson, Stuart E.,Fillery, Shaun M.,Goldberg, Kristin,Demeritt, Julie E.,Eden, Jonathan,Finlayson, Jonathan,Patel, Anil. "Synthesis of Indole-Dihydroisoquinoline Sulfonyl Ureas via Three-Component Reactions". . p. 4963 - 4981. Retrieved 2018/12/13.
• 2、 -. "COMPOUNDS AND COMPOSITIONS AS PDGFR KINASE INHIBITORS". Page/Page column 72; 79. . Retrieved 2013/03/28.