4-NITRO METHANESULFONANILIDE

Base Information

• Chemical Name: 4-NITRO METHANESULFONANILIDE
• CAS No.: 5825-62-7
• Molecular Formula: C7H8N2O4S
• Molecular Weight: 216.218
• Hs Code.: 2921420090
• Mol file: 5825-62-7.mol

Synonyms:4-NITRO METHANESULFONANILIDE

Chemical Property of 4-NITRO METHANESULFONANILIDE

Chemical Property:

• Melting Point: 186 °C
• Boiling Point: 380.7±44.0 °C(Predicted)
• PKA: 6.14±0.10(Predicted)
• PSA: 100.37000
• Density: 1.525±0.06 g/cm3(Predicted)
• LogP: 2.64330
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

N-(4-Nitrophenyl)methanesulfonamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-NITRO METHANESULFONANILIDE

There total 9 articles about 4-NITRO METHANESULFONANILIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methanesulfonyl chloride (124-63-0) + 4-nitro-aniline (100-01-6,104810-17-5) → N-(4-nitrophenyl)methanesulfonamide (5825-62-7)

Guidance literature:

With pyridine;

DOI:10.1016/j.bmcl.2005.06.009

Reference yield: 95.0%

4-nitro-aniline (100-01-6,104810-17-5) + Methanesulfonic anhydride (7143-01-3) → N-(4-nitrophenyl)methanesulfonamide (5825-62-7)

Guidance literature:

4-nitro-aniline; Methanesulfonic anhydride; With triethylamine; In dichloromethane; at 20 ℃;

With sodium hydroxide; In methanol; water; at 20 ℃;

DOI:10.1016/j.tetlet.2008.08.054

Reference yield: 82.0%

C21H25N4O5S(1+)*F6P(1-) → N-(4-nitrophenyl)methanesulfonamide (5825-62-7)

Guidance literature:

With trifluoroacetic acid; for 10h;

DOI:10.1021/co200149m

upstream raw materials:

methanesulfonyl chloride

4-nitro-aniline

N-nitroso-methanesulfonanilide

1-methanesulfonyloxy-1,2,3-benzotriazole

Downstream raw materials:

N-(2,4-dinitrophenyl)methanesulfonamide

p-(methylsulfonamido)aniline

N-(4-aminophenyl)-N-(2-(dimethylamino)ethyl)methanesulfonamide

N-(2-(dimethylamino)ethyl)-N-(4-nitrophenyl)methanesulfonamide

Refernces

• 1、 Schoene, Jens,Gazzi, Thais,Lindemann, Peter,Christmann, Mathias,Volkamer, Andrea,Nazaré, Marc. "Probing 2H-Indazoles as Templates for SGK1, Tie2, and SRC Kinase Inhibitors". . p. 1514 - 1527. Retrieved 2019/08/07.
• 2、 -. "Amide compound for prevention and treatment of mental disorders". Paragraph 0150; 0152; 0153. . Retrieved 2019/01/08.