AKOS B018337

Base Information

• Chemical Name: AKOS B018337
• CAS No.: 50459-52-4
• Molecular Formula: C11H9NOS2
• Molecular Weight: 235.33
• Hs Code.: 2934999090
• Mol file: 50459-52-4.mol

Synonyms:ART-CHEM-BB B018337;CHEMBRDG-BB 3018337;AKOS B018337;(5E)-2-mercapto-5-(2-methylbenzylidene)-1,3-thiazol-4(5H)-one

Chemical Property of AKOS B018337

Chemical Property:

• Vapor Pressure: 1.08E-05mmHg at 25°C
• Refractive Index: 1.708
• Boiling Point: 370.8°C at 760 mmHg
• Flash Point: 178°C
• PSA: 93.53000
• Density: 1.38g/cm³
• LogP: 2.33070

Purity/Quality:

98%min ^*data from raw suppliers

(5Z)-5-(2-Methylbenzylidene)-2-sulfanyl-1,3-thiazol-4(5H)-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of AKOS B018337

There total 3 articles about AKOS B018337 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2-thioxo-4-thiazolidinone (141-84-4) + 2-methylphenyl aldehyde (529-20-4) → C11H9NOS2 (50459-52-4)

Guidance literature:

With sodium acetate; acetic acid; for 7h; Inert atmosphere; Reflux;

Reference yield: 75.0%

2-thioxo-4-thiazolidinone (141-84-4) + 2-methylphenyl aldehyde (529-20-4) → (Z)-5-(3'-methylbenzylidene)-2-thioxothiazolidin-4-one (50459-52-4)

Guidance literature:

With ammonium acetate; In toluene; at 110 ℃; for 12h;

DOI:10.1016/j.bmc.2008.11.032

Reference yield:

→ (Z)-5-(3'-methylbenzylidene)-2-thioxothiazolidin-4-one (50459-52-4)

Guidance literature:

/BRN= 165827/;

DOI:10.1039/jr9510001213 DOI:10.1021/jo01147a028

upstream raw materials:

2-thioxo-4-thiazolidinone

2-methylphenyl aldehyde

Refernces

• 1、 Russell, Angela J.,Westwood, Isaac M.,Crawford, Matthew H.J.,Robinson, James,Kawamura, Akane,Redfield, Christina,Laurieri, Nicola,Lowe, Edward D.,Davies, Stephen G.,Sim, Edith. "Selective small molecule inhibitors of the potential breast cancer marker, human arylamine N-acetyltransferase 1, and its murine homologue, mouse arylamine N-acetyltransferase 2". experimental part. p. 905 - 918. Retrieved 2009/09/25.