Mivobulin

Base Information

• Chemical Name: Mivobulin
• CAS No.: 122332-18-7
• Molecular Formula: C17H19N5O2
• Molecular Weight: 325.37
• Mol file: 122332-18-7.mol

Synonyms:Carbamicacid, (5-amino-1,2-dihydro-2-methyl-3-phenylpyrido[3,4-b]pyrazin-7-yl)-, ethylester, (S)-;Carbamic acid,[(2S)-5-amino-1,2-dihydro-2-methyl-3-phenylpyrido[3,4-b]pyrazin-7-yl]-, ethylester (9CI);(S)-(-)-NSC 613862;Mivobulin;NSC 613862;

Chemical Property of Mivobulin

Chemical Property:

• Vapor Pressure: 1.74E-09mmHg at 25°C
• Refractive Index: 1.671
• Boiling Point: 483 °C at 760 mmHg
• Flash Point: 245.9 °C
• PSA: 57.61000
• Density: 1.36 g/cm³
• LogP: 2.90650

Purity/Quality:

99% ^*data from raw suppliers

MIVOBULIN 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Antineoplastic (microtubule inhibitor).

Technology Process of Mivobulin

There total 5 articles about Mivobulin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

ethyl (S)-6-amino-4-<(1-methyl-2-oxo-2-phenylethyl)-amino>-5-nitropyridine-2-carbamate (122293-99-6) → ethyl <(S)-5-amino-1,2-dihydro-2-methyl-3-phenylpyrido<3,4-b>pyrazin-7-yl>carbamate (122332-18-7,122293-95-2)

Guidance literature:

With hydrogen; nickel; In acetic acid; under 760 Torr;

DOI:10.1021/jm00129a012

Reference yield:

(1R,2S)-norephedrine (492-41-1,58550-13-3,757124-50-8) → ethyl <(S)-5-amino-1,2-dihydro-2-methyl-3-phenylpyrido<3,4-b>pyrazin-7-yl>carbamate (122332-18-7,122293-95-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 73 percent / Et₃N / ethanol / Heating

2: 53 percent / CrO₃, pyridine / CH₂Cl₂

3: 41 percent / H₂ / Raney-Nickel / acetic acid / 760 Torr

With pyridine; chromium(VI) oxide; hydrogen; triethylamine; nickel; In ethanol; dichloromethane; acetic acid;

DOI:10.1021/jm00129a012

Reference yield:

ethyl (6-amino-4-chloro-5-nitropyridin-2-yl)carbamate (6506-86-1) → ethyl <(S)-5-amino-1,2-dihydro-2-methyl-3-phenylpyrido<3,4-b>pyrazin-7-yl>carbamate (122332-18-7,122293-95-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 73 percent / Et₃N / ethanol / Heating

2: 53 percent / CrO₃, pyridine / CH₂Cl₂

3: 41 percent / H₂ / Raney-Nickel / acetic acid / 760 Torr

With pyridine; chromium(VI) oxide; hydrogen; triethylamine; nickel; In ethanol; dichloromethane; acetic acid;

DOI:10.1021/jm00129a012

upstream raw materials:

ethyl (S)-6-amino-4-<(1-methyl-2-oxo-2-phenylethyl)-amino>-5-nitropyridine-2-carbamate

(1R,2S)-norephedrine

ethyl (6-amino-4-chloro-5-nitropyridin-2-yl)carbamate

ethyl -6-amino-4-<(2-hydroxy-1-methyl-2-phenylethyl)amino>-5-nitropyridine-2-carbamate

Refernces

• 1、 -. "'(2S)-(5-amino-1,2-dihydro-2-methyl-3-phenylpyrido(3,4-b)pyrazin-7-yl)-carbamic acid, ethyl ester". . . Retrieved 2008/06/13.