(3-Fluorophenyl)hydrazine

Base Information

• Chemical Name: (3-Fluorophenyl)hydrazine
• CAS No.: 658-27-5
• Molecular Formula: C6H7FN2
• Molecular Weight: 126.133
• Hs Code.: 2928000090
• DSSTox Substance ID: DTXSID40342350
• Nikkaji Number: J84A
• Wikidata: Q82113084
• Mol file: 658-27-5.mol

Synonyms:(3-fluorophenyl)hydrazine;658-27-5;3-Fluorophenylhydrazine;Hydrazine, (3-fluorophenyl)-;(3-Fluoro-phenyl)-hydrazine;3-FLUORO-PHENYL-HYDRAZINE;m-Fluorophenylhydrazine;3-fluoro-phenylhydrazine;3-fluorophenyl hydrazine;(m-Fluorophenyl)hydrazine;1-(3-Fluorophenyl)hydrazine;Hydrazine, (m-fluorophenyl)-;1-(3-fluorophenyl) hydrazine;SCHEMBL1143757;1-(3-Fluorophenyl)hydrazine #;DTXSID40342350;BBL012159;MFCD00041261;STK397822;AKOS000160533;GS-3461;BB 0249783;EN300-53731;A903027

Chemical Property of (3-Fluorophenyl)hydrazine

Chemical Property:

• Melting Point: 28 °C(Solv: ligroine (8032-32-4))
• Boiling Point: 88 °C(Press: 2 Torr)
• PKA: 5.06±0.10(Predicted)
• PSA: 38.05000
• Density: 1.257±0.06 g/cm3(Predicted)
• LogP: 1.88460
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 126.05932639
• Heavy Atom Count: 9
• Complexity: 87.1

Purity/Quality:

99% ^*data from raw suppliers

3-Fluorophenylhydrazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC(=C1)F)NN

Technology Process of (3-Fluorophenyl)hydrazine

There total 3 articles about (3-Fluorophenyl)hydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.81%

meta-fluoroaniline (372-19-0) → m-fluorophenylhydrazine (658-27-5)

Guidance literature:

meta-fluoroaniline; With hydrogenchloride; sodium nitrite; In water; for 2h;

With hydrogenchloride; sodium sulfite; In water; at 0 - 100 ℃; for 4h;

DOI:10.1016/j.ejmech.2016.04.062

Reference yield:

3-fluorobromobenzene (1073-06-9) → m-fluorophenylhydrazine (658-27-5)

Guidance literature:

With potassium phosphate; copper(l) iodide; hydrazine hydrate; at 120 ℃; for 10h; Sealed tube; Inert atmosphere;

DOI:10.1016/j.tet.2012.11.014

Reference yield:

→ m-fluorophenylhydrazine (658-27-5)

Guidance literature:

/BRN= 637073/;

upstream raw materials:

meta-fluoroaniline

3-fluorobromobenzene

Downstream raw materials:

D-arabino-[2]hexosulose-bis-(3-fluoro-phenylhydrazone)

5-amino-1-(3-fluorophenyl)-1H-pyrazole-4-carbonitrile

2-fluoro-9H-carbazole

ethyl 4-[N'-(3-fluorophenyl)hydrazino]-1-methyl-6-(5-bromo-3-pyridinyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxylate

Refernces

• 1、 Gao, Li,Li, Huangong,Li, Yuxin,Li, Zhengming,Ma, Yi,Meng, Fanfei,Sun, Binqiao,Sun, Pengwei,Xie, Yongtao,Xiong, Lixia,Yang, Na,Zhang, Yan,Zhao, Yangyang,Zhou, Sha. "Synthesis, insecticidal activities, and structure-activity relationship of phenylpyrazole derivatives containing a fluoro-substituted benzene moiety". . p. 11282 - 11289. Retrieved 2020/11/09.
• 2、 -. "Preparation method of 3-fluorophenylhydrazine sulfate". Paragraph 0037-0042. . Retrieved 2017/06/20.