4-CHLORO -2,6 DIMETHYL PYRIDINE-N-OXIDE

Base Information

• Chemical Name: 4-CHLORO -2,6 DIMETHYL PYRIDINE-N-OXIDE
• CAS No.: 697-92-7
• Molecular Formula: C₇H₈ClNO
• Molecular Weight: 157.6
• Hs Code.: 2933399090
• Mol file: 697-92-7.mol

Synonyms:2,6-Lutidine,4-chloro-, 1-oxide (7CI,8CI); 4-Chloro-2,6-dimethylpyridine N-oxide

Chemical Property of 4-CHLORO -2,6 DIMETHYL PYRIDINE-N-OXIDE

Chemical Property:

• PSA: 25.46000
• LogP: 2.38530

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-CHLORO-2,6-DIMETHYLPYRIDINE-1-OXIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-CHLORO -2,6 DIMETHYL PYRIDINE-N-OXIDE

There total 3 articles about 4-CHLORO -2,6 DIMETHYL PYRIDINE-N-OXIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

4-chloro-2,6-lutidine (3512-75-2) → 2,6-dimethyl-4-chloropyridine N-oxide (697-92-7)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 - 23 ℃; for 24h;

DOI:10.1021/acs.orglett.9b02054

Reference yield: 17.0%

4-nitro-2,6-lutidine-1-oxide (4808-64-4) → 2,6-dimethyl-4-chloropyridine N-oxide (697-92-7)

Guidance literature:

With triethylbutylammonium chloride; ethenetetracarbonitrile; In acetonitrile; at 65 ℃; for 5h;

DOI:10.1134/S1070428008120191

Reference yield:

→ 2,6-dimethyl-4-chloropyridine N-oxide (697-92-7)

Guidance literature:

2,6-Dimethyl-4-nitropyridin-N-oxid, 1) Acetylchlorid, Δ (-> Hydrochlorid), 2) NaHCO3;

DOI:10.1039/jr9650002096

upstream raw materials:

4-chloro-2,6-lutidine

4-nitro-2,6-lutidine-1-oxide

Downstream raw materials:

2,6-dimethyl-1-phenylpyridin-4(1H)-one

acetic 4-chloro-6-methyl-2-pyridinylmethyl ester

4-chloro-6-methylpicolinaldehyde

4-chloro-2,6-dimethyl-pyridin-3-ol

Refernces

• 1、 Nizhnik,Andreev,Belashev. "Molecular complexes of 4-nitropyridine and 4-nitroquinoline N-oxides with boron trifluoride and hydrogen chloride as intermediates in SNAr reactions". scheme or table. p. 1824 - 1830. Retrieved 2009/09/06.