1-Methylindoline-5-carboxaldehyde 97%

Base Information

• Chemical Name: 1-Methylindoline-5-carboxaldehyde 97%
• CAS No.: 60082-02-2
• Molecular Formula: C10H11NO
• Molecular Weight: 161.203
• Hs Code.: 2933990090
• Mol file: 60082-02-2.mol

Synonyms:1-Methylindoline-5-carboxaldehyde 97%;1-Methylindoline-5-carboxaldehyde;2,3-Dihydro-1-methyl-1H-indole-5-carboxaldehyde;2,3-Dihydro-1-methyl-1H-indole-5-carboxaldehyde, 5-Formyl-1-methylindoline

Chemical Property of 1-Methylindoline-5-carboxaldehyde 97%

Chemical Property:

• Vapor Pressure: 0.000249mmHg at 25°C
• Refractive Index: 1.608
• Boiling Point: 324.2 °C at 760 mmHg
• Flash Point: 137.3 °C
• PSA: 20.31000
• Density: 1.141 g/cm³
• LogP: 1.55640

Purity/Quality:

98% ^*data from raw suppliers

1-methyl-2,3-dihydro-1H-indole-5-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Methylindoline-5-carboxaldehyde 97%

There total 4 articles about 1-Methylindoline-5-carboxaldehyde 97% which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

N-methylindoline (824-21-5) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 1-methylindoline-5-carboxaldehyde (60082-02-2)

Guidance literature:

With trichlorophosphate;

DOI:10.1080/00304949809355310

Reference yield:

1-indoline (496-15-1) → 1-methylindoline-5-carboxaldehyde (60082-02-2)

Guidance literature:

Multi-step reaction with 3 steps

1: toluene / 2.5 h / Dean-Stark; Reflux

2: lithium aluminium tetrahydride / diethyl ether / 19 h / Reflux

3: trichlorophosphate / 4 h / 0 - 85 °C

With lithium aluminium tetrahydride; trichlorophosphate; In diethyl ether; toluene;

DOI:10.1002/ejoc.201800835

Reference yield:

N-formylindoline (2861-59-8) → 1-methylindoline-5-carboxaldehyde (60082-02-2)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / diethyl ether / 19 h / Reflux

2: trichlorophosphate / 4 h / 0 - 85 °C

With lithium aluminium tetrahydride; trichlorophosphate; In diethyl ether;

DOI:10.1002/ejoc.201800835

upstream raw materials:

N-methylindoline

N,N-dimethyl-formamide

1-indoline

N-formylindoline

Downstream raw materials:

1-methyl-1H-indole-5-carboxaldehyde

N-methylindoline-5-carboxylic acid

1-methyl-5-indole

1-methyl-5-indoline

Refernces

• 1、 Kool, Jeroen,De Kloe, Gerdien E.,Bruyneel, Ben,De Vlieger, Jon S.,Retra, Kim,Wijtmans, Maikel,Van Elk, Rene,Smit, August B.,Leurs, Rob,Lingeman, Henk,De Esch, Iwan J.P.,Irth, Hubertus. "Online fluorescence enhancement assay for the acetylcholine binding protein with parallel mass spectrometric identification". experimental part. p. 4720 - 4730. Retrieved 2010/10/03.