1-FORMYLINDOLINE

Base Information

• Chemical Name: 1-FORMYLINDOLINE
• CAS No.: 2861-59-8
• Molecular Formula: C9H9 N O
• Molecular Weight: 147.177
• Hs Code.: 2933990090
• Mol file: 2861-59-8.mol

Synonyms:1-Indolinecarboxaldehyde(6CI,7CI,8CI); 2,3-Dihydroindole-1-carboxaldehyde; N-Formylindoline

Chemical Property of 1-FORMYLINDOLINE

Chemical Property:

• Vapor Pressure: 0.00212mmHg at 25°C
• Melting Point: 63-65°C
• Refractive Index: 1.681
• Boiling Point: 165°C 8mm
• PKA: 1.12±0.20(Predicted)
• Flash Point: 136.5°C
• PSA: 20.31000
• Density: 1.266g/cm³
• LogP: 1.90640
• Solubility.: Dichloromethane, Ethyl Acetate, Methanol

Purity/Quality:

NLT 98% ^*data from raw suppliers

N-Formylindoline ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Indoline metabolite

Technology Process of 1-FORMYLINDOLINE

There total 4 articles about 1-FORMYLINDOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

indole (120-72-9) → 1-indoline (496-15-1) + N-formylindoline (2861-59-8)

Guidance literature:

With formic acid; palladium on activated charcoal; at 70 ℃; for 0.5h;

DOI:10.1055/s-1982-29946

Reference yield:

indole (120-72-9) + formic acid (64-18-6) → 1-indoline (496-15-1) + N-formylindoline (2861-59-8)

Guidance literature:

With palladium 10% on activated carbon; In isopropyl alcohol; at 80 ℃; for 0.5h;

DOI:10.1055/s-0030-1259978

Reference yield:

1-(2-bromoethyl)-2-isocyanatobenzene (511302-92-4) → N-formylindoline (2861-59-8) + 3,4-dihydro-2(1H)-quinolone (553-03-7) + 2-ethylphenyl isocyanate (40411-25-4) + 1-(2,3-dihydroindol-1-yl)-3,4-dihydro-1H-quinolin-2-one

Guidance literature:

With tri-n-butyl-tin hydride; In benzene; at 30 ℃; for 3h; Title compound not separated from byproducts; Photolysis;

DOI:10.1021/jo034002o

upstream raw materials:

indole

1-(2-bromoethyl)-2-isocyanatobenzene

formic acid

Downstream raw materials:

1-cyanomethylindoline

1-methylindoline-5-carboxaldehyde

5-bromo-1H-indole

1-indoline

Refernces

• 1、 Minin, Patricia L.,Walton, John C.. "Radical ring closures of 4-isocyanato carbon-centered radicals". . p. 2960 - 2963. Retrieved 2007/10/03.