(4-phenoxyphenyl)hydrazine Hydrochloride

Base Information

• Chemical Name: (4-phenoxyphenyl)hydrazine Hydrochloride
• CAS No.: 60481-02-9
• Molecular Formula: C12H13ClN2O
• Molecular Weight: 236.701
• Hs Code.: 2928000090
• European Community (EC) Number: 674-312-6
• DSSTox Substance ID: DTXSID20375449
• Mol file: 60481-02-9.mol

Synonyms:60481-02-9;(4-phenoxyphenyl)hydrazine Hydrochloride;4-Phenoxyphenylhydrazine hydrochloride;4-(phenoxy)phenylhydrazine hydrochloride;(4-phenoxyphenyl)hydrazine;hydrochloride;(4-phenoxy-phenyl)-hydrazine hydrochloride;1-(4-phenoxyphenyl)hydrazine hydrochloride;MFCD03426044;(4-PHENOXY-PHENYL)-HYDRAZINE HCL;Hydrazine, (4-phenoxyphenyl)-, monohydrochloride;SCHEMBL4370006;DTXSID20375449;BFNBYPAMZTYWBT-UHFFFAOYSA-N;BCP33689;(4-phenoxyphenyl)diazane hydrochloride;4-phenoxyphenyl hydrazine hydrochloride;AKOS015848682;AB14755;CS-0211474;FT-0640692;EN300-69166;F13034;A832747;(4-Phenoxy-phenyl)-hydrazine hydrochloride, AldrichCPR

Chemical Property of (4-phenoxyphenyl)hydrazine Hydrochloride

Chemical Property:

• Melting Point: 187-189(dec.)
• Boiling Point: 352.9 °C at 760 mmHg
• Flash Point: 167.2 °C
• PSA: 47.28000
• LogP: 4.33980
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 236.0716407
• Heavy Atom Count: 16
• Complexity: 173

Purity/Quality:

98%,99%, ^*data from raw suppliers

(4-Phenoxyphenyl)hydrazineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)OC2=CC=C(C=C2)NN.Cl

Technology Process of (4-phenoxyphenyl)hydrazine Hydrochloride

There total 3 articles about (4-phenoxyphenyl)hydrazine Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

4-Bromodiphenyl ether (101-55-3) → (4-phenoxyphenyl)hydrazine hydrochloride (60481-02-9)

Guidance literature:

4-Bromodiphenyl ether; With potassium phosphate; copper(l) iodide; N,N′-bis(2,6-dimethylphenyl)oxalamide; cetyltrimethylammonim bromide; In water; at 80 ℃; for 0.25h; Schlenk technique; Inert atmosphere; Sealed tube;

With hydrazine hydrate; In water; at 80 ℃; Inert atmosphere; Schlenk technique; Sealed tube;

With hydrogenchloride; In water; pH=3 - 4; Inert atmosphere; Schlenk technique; Sealed tube;

DOI:10.1002/cjoc.201800326

Reference yield: 44.0%

4-phenoxyanilin (139-59-3) → (4-phenoxyphenyl)hydrazine hydrochloride (60481-02-9)

Guidance literature:

4-phenoxyanilin; With hydrogenchloride; sodium nitrite; In water; at 0 ℃; for 1h;

With hydrogenchloride; tin(II) chloride dihdyrate; aminosulfonic acid; at 0 ℃; for 2h;

DOI:10.1016/j.ejmech.2012.10.040

Reference yield:

4-Phenoxy-benzoldiazonium-chlorid (6099-72-5) → (4-phenoxyphenyl)hydrazine hydrochloride (60481-02-9)

Guidance literature:

With hydrogenchloride; tin(ll) chloride; at 0 ℃; for 1h;

DOI:10.1021/acs.jafc.0c03736

upstream raw materials:

4-phenoxyanilin

4-Bromodiphenyl ether

4-Phenoxy-benzoldiazonium-chlorid

Downstream raw materials:

methyl 2-(4-phenoxyphenyl)hydrazinecarboxylate

Refernces

• 1、 Kumar, Siripuram Vijay,Ma, Dawei. "Synthesis of Aryl Hydrazines via CuI/BMPO Catalyzed Cross-Coupling of Aryl Halides with Hydrazine Hydrate in Water". supporting information. p. 1003 - 1006. Retrieved 2018/09/20.
• 2、 Wang, Ziqian,Song, Ting,Feng, Yingang,Guo, Zongwei,Fan, Yudan,Xu, Wenjie,Liu, Lu,Wang, Anhui,Zhang, Zhichao. "Bcl-2/MDM2 Dual Inhibitors Based on Universal Pyramid-Like α-Helical Mimetics". supporting information. p. 3152 - 3162. Retrieved 2016/05/19.