Benzofuran, 5-fluoro-2-methyl-

Base Information

• Chemical Name: Benzofuran, 5-fluoro-2-methyl-
• CAS No.: 60770-66-3
• Molecular Formula: C9H7FO
• Molecular Weight: 150.15
• Mol file: 60770-66-3.mol

Synonyms:Benzofuran, 5-fluoro-2-methyl-

Chemical Property of Benzofuran, 5-fluoro-2-methyl-

Chemical Property:

• Boiling Point: 75 °C (11 mmHg)
• PSA: 13.14000
• LogP: 2.88030

Purity/Quality:

5-fluoro-2-methyl-Benzofuran 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzofuran, 5-fluoro-2-methyl-

There total 12 articles about Benzofuran, 5-fluoro-2-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

5-Fluoro[b]benzofuran (24410-59-1) + methyl iodide (74-88-4) → 5-fluoro-2-methylbenzofuran (60770-66-3)

Guidance literature:

5-Fluoro[b]benzofuran; With tert.-butyl lithium; In tetrahydrofuran; hexane; at -78 ℃; for 2h; Inert atmosphere; Schlenk technique;

methyl iodide; In tetrahydrofuran; hexane; at 20 ℃; Inert atmosphere; Schlenk technique; Cooling;

DOI:10.1002/anie.202103910

Reference yield: 74.0%

calcium carbide + C14H13FN2O3S (1620151-29-2) → 5-fluoro-2-methylbenzofuran (60770-66-3)

Guidance literature:

With potassium tert-butylate; water; copper(l) chloride; In N,N-dimethyl-formamide; at 90 ℃; for 5h;

DOI:10.1021/acs.orglett.8b00676

Reference yield: 63.0%

C9H8BrFO → 5-fluoro-2-methylbenzofuran (60770-66-3)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine; In N,N-dimethyl-formamide; at 100 ℃; for 24h; Inert atmosphere;

DOI:10.1016/j.tetlet.2019.06.054

upstream raw materials:

3-(4-fluorophenoxy)-2-chloro-1-propene

2-(2-chloro-1-propen-3-yl)-4-fluorophenol

C₁₄H₁₃FN₂O₃S

2-bromo-4-fluoro-phenol

Downstream raw materials:

(5-Fluoro-benzofuran-2-yl)-acetonitrile

Refernces

• 1、 Zhou,Shi, Yuxing,Zhu, Xueyan,Zhang, Peng. "Pd-catalyzed intramolecular Heck reaction for the synthesis of 2-methylbenzofurans". . p. 2005 - 2008. Retrieved 2019/07/03.
• 2、 Zhang, Yin Jun,Wang, Yu Guang. "An efficient solid-phase synthesis of substituted benzofuran using selenium-bound resin". experimental part. p. 212 - 216. Retrieved 2012/07/13.