1,3-Cyclopentanediamine,cis-(9CI)

Base Information

• Chemical Name: 1,3-Cyclopentanediamine,cis-(9CI)
• CAS No.: 63486-45-3
• Molecular Formula: C5H12N2
• Molecular Weight: 100.164
• Mol file: 63486-45-3.mol

Synonyms:1,3-Cyclopentanediamine,cis-(9CI)

Chemical Property of 1,3-Cyclopentanediamine,cis-(9CI)

Chemical Property:

• Boiling Point: 172.7±8.0 °C(Predicted)
• PKA: 10.84±0.40(Predicted)
• PSA: 52.04000
• Density: 0.964±0.06 g/cm3(Predicted)
• LogP: 1.22550
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98%Min ^*data from raw suppliers

cis-Cyclopentane-1,3-diamine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,3-Cyclopentanediamine,cis-(9CI)

There total 7 articles about 1,3-Cyclopentanediamine,cis-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

C13H16N4O2 → (1R,3S)-cyclopentane-1,3-diamine (63486-45-3)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 30 ℃; for 16h;

Reference yield:

(2-furyl)methyl alcohol (98-00-0,25212-86-6,93793-62-5) → (1R,3S)-cyclopentane-1,3-diamine (63486-45-3) + (+/-)-trans-1,3-diamino-cyclopentane

Guidance literature:

Multi-step reaction with 4 steps

1: water / 0.17 h / 200 °C / Microwave irradiation; Sealed tube; Green chemistry

2: 1-hydroxytetraphenylcyclopentadienyl(tetraphenyl-2,4-cyclopentadien-1-one)-μ-hydrotetracarbonyldiruthenium(II) / 2-methyltetrahydrofuran / 4 h / 80 °C / Schlenk technique; Inert atmosphere; Sealed tube; Green chemistry

3: hydroxylamine / water / 1 h / 20 °C / Green chemistry

4: rhodium contaminated with carbon; hydrogen / isopropyl alcohol / 3 h / 40 °C / 37503.8 Torr / Sealed tube; Autoclave; Green chemistry

With 1-hydroxytetraphenylcyclopentadienyl(tetraphenyl-2,4-cyclopentadien-1-one)-μ-hydrotetracarbonyldiruthenium(II); rhodium contaminated with carbon; hydrogen; hydroxylamine; In 2-methyltetrahydrofuran; water; isopropyl alcohol;

DOI:10.1039/d1gc02372a

Reference yield:

4-Hydroxycyclopent-2-enone (59995-47-0,59995-49-2,61305-27-9,61740-29-2) → (1R,3S)-cyclopentane-1,3-diamine (63486-45-3) + (+/-)-trans-1,3-diamino-cyclopentane

Guidance literature:

Multi-step reaction with 3 steps

1: 1-hydroxytetraphenylcyclopentadienyl(tetraphenyl-2,4-cyclopentadien-1-one)-μ-hydrotetracarbonyldiruthenium(II) / 2-methyltetrahydrofuran / 4 h / 80 °C / Schlenk technique; Inert atmosphere; Sealed tube; Green chemistry

2: hydroxylamine / water / 1 h / 20 °C / Green chemistry

3: rhodium contaminated with carbon; hydrogen / isopropyl alcohol / 3 h / 40 °C / 37503.8 Torr / Sealed tube; Autoclave; Green chemistry

With 1-hydroxytetraphenylcyclopentadienyl(tetraphenyl-2,4-cyclopentadien-1-one)-μ-hydrotetracarbonyldiruthenium(II); rhodium contaminated with carbon; hydrogen; hydroxylamine; In 2-methyltetrahydrofuran; water; isopropyl alcohol;

DOI:10.1039/d1gc02372a

upstream raw materials:

(2-furyl)methyl alcohol

4-Hydroxycyclopent-2-enone

1,3-cyclopentadione

cyclopentane-1,3-dioxime

Refernces

• 1、 -. "TETRACYCLIC HETEROCYCLE COMPOUNDS USEFUL AS HIV INTEGRASE INHIBITORS". Page/Page column 37; 38. . Retrieved 2015/04/15.