Pyrazinecarbonitrile, 3-amino-6-formyl- (9CI)

Base Information

• Chemical Name: Pyrazinecarbonitrile, 3-amino-6-formyl- (9CI)
• CAS No.: 64440-74-0
• Molecular Formula: C₆H₄N₄O
• Molecular Weight: 148.124
• Mol file: 64440-74-0.mol

Synonyms:Pyrazinecarbonitrile,3-amino-6-formyl- (9CI)

Chemical Property of Pyrazinecarbonitrile, 3-amino-6-formyl- (9CI)

Chemical Property:

• PSA: 92.66000
• LogP: 0.32418

Purity/Quality:

99% ^*data from raw suppliers

3-amino-6-formyl-2-Pyrazinecarbonitrile 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyrazinecarbonitrile, 3-amino-6-formyl- (9CI)

There total 5 articles about Pyrazinecarbonitrile, 3-amino-6-formyl- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

3-amino-6-{[(4-dimethylamino-phenyl)-oxy-imino]-methyl}-pyrazine-2-carbonitrile (64440-76-2) → 2-amino-3-cyano-5-formylpyrazine (64440-74-0)

Guidance literature:

With hydrogenchloride; In water;

DOI:10.1016/j.bmcl.2016.07.006

Reference yield: 60.2%

N-[p-(dimethylamino)phenyl]-α-(2-amino-3-cyano-5-pyrazinyl)nitrone (64440-76-2) → 2-amino-3-cyano-5-formylpyrazine (64440-74-0)

Guidance literature:

With hydrogenchloride;

DOI:10.1021/jf025571k

Reference yield:

1-[(2-amino-3-cyano-5-pyrazinyl)methyl]pyridinium chloride (64440-75-1) → 2-amino-3-cyano-5-formylpyrazine (64440-74-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 75.7 percent / aq. K₂CO₃ / ethanol / 0.5 h / 20 °C

2: 60.2 percent / aq. HCl

With hydrogenchloride; potassium carbonate; In ethanol;

DOI:10.1021/jf025571k

upstream raw materials:

N-[p-(dimethylamino)phenyl]-α-(2-amino-3-cyano-5-pyrazinyl)nitrone

1-[(2-amino-3-cyano-5-pyrazinyl)methyl]pyridinium chloride

2-Amino-5-chloromethylpyrazine-3-carbonitrile

3-amino-6-(chloromethyl)-2-pyrazinecarbonitrile 4-oxide

Refernces

• 1、 Freisleben, Achim,Schieberle, Peter,Rychlik, Michael. "Syntheses of labeled vitamers of folic acid to be used as internal standards in stable isotope dilution assays". . p. 4760 - 4768. Retrieved 2007/10/03.