1-BROMODIFLUORMETHYL-2-METHYLBENZIMIDAZOLE

Base Information

• Chemical Name: 1-BROMODIFLUORMETHYL-2-METHYLBENZIMIDAZOLE
• CAS No.: 273405-42-8
• Molecular Formula: C9H7 Br F2 N2
• Molecular Weight: 261.06600
• Mol file: 273405-42-8.mol

Synonyms:1-Bromodifluoromethyl-2-methylbenzimidazole;

Chemical Property of 1-BROMODIFLUORMETHYL-2-METHYLBENZIMIDAZOLE

Chemical Property:

• Vapor Pressure: 0.007mmHg at 25°C
• Boiling Point: 280.174oC at 760 mmHg
• Flash Point: 123.245oC
• PSA: 17.82000
• Density: 1.644g/cm3
• LogP: 3.24640

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-BROMODIFLUORMETHYL-2-METHYLBENZIMIDAZOLE

There total 1 articles about 1-BROMODIFLUORMETHYL-2-METHYLBENZIMIDAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

2-Methyl-1H-benzimidazole (615-15-6) + dibromodifluoromethane (75-61-6) → 1-Bromodifluoromethyl-2-methylbenzimidazole (273405-42-8)

Guidance literature:

2-Methyl-1H-benzimidazole; With sodium hydride; zinc; In acetonitrile; at -10 - -5 ℃; for 3h;

dibromodifluoromethane; With zinc; In acetonitrile; at 20 ℃; for 14h;

DOI:10.1016/S0040-4039(00)00148-9

Reference yield: 95.0%

1-Bromodifluoromethyl-2-methylbenzimidazole (273405-42-8) → 1-(difluoromethyl)-2-methyl-1H-benzo[d]imidazole (84941-16-2)

Guidance literature:

With water; zinc; In methanol; at 20 ℃; for 24h;

DOI:10.1016/S0022-1139(01)00390-6

Reference yield: 82.0%

chloro-trimethyl-silane (75-77-4) + 1-Bromodifluoromethyl-2-methylbenzimidazole (273405-42-8) → 2-Methylbenzimidazole-1-yldifluoromethyltrimethylsilane (341529-09-7)

Guidance literature:

With P(NEt)3; In dichloromethane; at -70 ℃; for 1h;

DOI:10.1055/s-2001-11389

upstream raw materials:

2-Methyl-1H-benzimidazole

dibromodifluoromethane

Downstream raw materials:

2-Methylbenzimidazol-1-yl-2,2-difluoro-1-phenylethanol

2-Methylbenzimidazole-1-yldifluoromethyltrimethylsilane

1-(difluoromethyl)-2-methyl-1H-benzo[d]imidazole

2-Methyl-1-trifluoromethylbenzimidazole

Refernces

• 1、 Yagupolskii, Lev M.,Fedyuk, Dmitrij V.. "2-Alkyl-1-(2-aryl-1,1-difluoro-2-hydroxyethyl)benzimidazoles: Potential angiotensin II receptor antagonists". . p. 2265 - 2267. Retrieved 2000.