(R)-3-Phenylpiperidine

Base Information

• Chemical Name: (R)-3-Phenylpiperidine
• CAS No.: 430461-56-6
• Molecular Formula: C11H15N
• Molecular Weight: 161.247
• Hs Code.: 2933399990
• European Community (EC) Number: 676-313-7
• Nikkaji Number: J1.680.180A
• Mol file: 430461-56-6.mol

Synonyms:(R)-3-Phenylpiperidine;430461-56-6;(R)-3-Phenyl piperidine;(3R)-3-PHENYLPIPERIDINE;(R)-3-PHENYL-PIPERIDINE;PIPERIDINE, 3-PHENYL-, (3R)-;R)-3-PHENYL PIPERIDINE;MFCD03839934;3beta-Phenylpiperidine;SCHEMBL381572;NZYBILDYPCVNMU-NSHDSACASA-N;AKOS006238135;AKOS015840989;DS-1825;A6972;CS-0045017;(R)-3-phenylpiperidine;Q-102140

Chemical Property of (R)-3-Phenylpiperidine

Chemical Property:

• Vapor Pressure: 0.0104mmHg at 25°C
• Melting Point: 179-181℃
• Refractive Index: 1.522
• Boiling Point: 263.183 °C at 760 mmHg
• PKA: 10.01±0.10(Predicted)
• Flash Point: 115.488 °C
• PSA: 12.03000
• Density: 0.967 g/cm³
• LogP: 2.48240
• Storage Temp.: 2-8°C(protect from light)
• XLogP3: 2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 161.120449483
• Heavy Atom Count: 12
• Complexity: 127

Purity/Quality:

95-99% ^*data from raw suppliers

(R)-3-Phenylpiperidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC(CNC1)C2=CC=CC=C2
• Isomeric SMILES: C1C[C@@H](CNC1)C2=CC=CC=C2

Technology Process of (R)-3-Phenylpiperidine

There total 18 articles about (R)-3-Phenylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

(3R)-1-[(1R)-2-hydroxy-1-phenylethyl]-3-phenylpiperidine (430461-53-3) → (R)-3-phenyl piperidine (430461-56-6)

Guidance literature:

With hydrogen; palladium dihydroxide; In ethyl acetate; at 25 ℃; for 25h;

DOI:10.1021/jo025894f

Reference yield: 72.0%

3-phenyl-3,6-dihydro-2H-pyridine-1-carboxylic acid benzyl ester → (R)-3-phenyl piperidine (430461-56-6)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; ethyl acetate;

DOI:10.1016/j.tetlet.2006.07.029

Reference yield: 23.5%

3-phenylpiperidine (3973-62-4) → (R)-3-phenyl piperidine (430461-56-6)

Guidance literature:

With Di-p-toluoyl-L-tartaric acid; In ethyl acetate; for 2h; Reagent/catalyst; Solvent;

upstream raw materials:

D-2-phenylglycinol

methyl 5-oxo-4-phenylpentanoate

(3R)-1-[(1R)-2-hydroxy-1-phenylethyl]-3-phenylpiperidine

((E)-(R)-2,4-Diphenyl-but-3-enyl)-carbamic acid benzyl ester

Downstream raw materials:

3-(4-hydroxy-1H-pyrazolo[4,3-c]pyridin-3-yl)-1-((R)-3-phenyl-piperidin-1-yl)-propan-1-one

(4-chlorophenyl)-carbamic acid (S)-2,2,2-trifluoro-1-((R)-3-phenylpiperidin-1-ylmethyl)-ethyl ester hydrochloride

C₃₂H₃₆N₂O₃

(2'S,3R,4'S)-1^,-(2,2-diphenylacetyl)-3-phenyl-[1,4'-bipiperidine]-2'-carboxylic acid

Refernces

• 1、 Nemoto, Tetsuhiro,Jin, Long,Nakamura, Hiroshi,Hamada, Yasumasa. "Pd-catalyzed asymmetric allylic alkylation with nitromethane using a chiral diaminophosphine oxide: (S,RP)-Ph-DIAPHOX. Enantioselective synthesis of (R)-preclamol and (R)-baclofen". . p. 6577 - 6581. Retrieved 2007/10/03.
• 2、 Amat, Mercedes,Canto, Margalida,Llor, Nuria,Escolano, Carmen,Molins, Elies,Espinosa, Enrique,Bosch, Joan. "Dynamic kinetic resolution of racemic γ-aryl-δ-oxoesters. Enantioselective synthesis of 3-arylpiperidines". . p. 5343 - 5351. Retrieved 2007/10/03.