methyl 5-oxo-4-phenylpentanoate

Base Information

• Chemical Name: methyl 5-oxo-4-phenylpentanoate
• CAS No.: 343947-52-4
• Molecular Formula: C₁₂H₁₄O₃
• Molecular Weight: 206.241
• Mol file: 343947-52-4.mol

Synonyms:methyl 5-oxo-4-phenylpentanoate

Chemical Property of methyl 5-oxo-4-phenylpentanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methyl 5-oxo-4-phenylpentanoate

There total 2 articles about methyl 5-oxo-4-phenylpentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

1-(2-phenylethynyl)piperidine (332-15-0) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → methyl 5-oxo-4-phenylpentanoate (343947-52-4)

Guidance literature:

1-(2-phenylethynyl)piperidine; acrylic acid methyl ester; In acetonitrile; for 36h; Heating;

With acetic acid; In acetonitrile; for 8h; Further stages.; Heating;

DOI:10.1021/jo025894f

Reference yield:

phenylacetaldehyde (122-78-1) → methyl 5-oxo-4-phenylpentanoate (343947-52-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 78 percent / Na₂CO₃ / 3 h / 0 °C

2.1: acetonitrile / 36 h / Heating

2.2: 45 percent / aqueous acetic acid / acetonitrile / 8 h / Heating

With sodium carbonate; In acetonitrile;

DOI:10.1021/jo025894f

Reference yield: 70.0%

D-2-phenylglycinol (56613-80-0) + methyl 5-oxo-4-phenylpentanoate (343947-52-4) → 3,8-diphenyl-hexahydro-oxazolo[3,2-a]pyridin-5-one

Guidance literature:

In toluene; for 14h; Heating;

DOI:10.1002/1521-3773(20020118)41

upstream raw materials:

1-(2-phenylethynyl)piperidine

acrylic acid methyl ester

phenylacetaldehyde

Downstream raw materials:

(R)-3-phenyl piperidine

(3R,8R,8aR)-3,8-diphenyl-5-oxo-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine

(3R,8S,8aS)-3,8-diphenyl-5-oxo-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine

(3R)-1-[(1R)-2-hydroxy-1-phenylethyl]-3-phenylpiperidine

Refernces