Dihydro ArteMisinin DiMer

Base Information

• Chemical Name: Dihydro ArteMisinin DiMer
• CAS No.: 150358-71-7
• Molecular Formula: C₃₀H₄₆O₉
• Molecular Weight: 550.69
• Mol file: 150358-71-7.mol

Synonyms:

Chemical Property of Dihydro ArteMisinin DiMer

Chemical Property:

• Melting Point: 140-142oC
• Storage Temp.: Refrigerator
• Solubility.: Chloroform

Purity/Quality:

HPLC ≥ 98% ^*data from raw suppliers

Dihydro Artemisinin Dimer ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Dihydro Artemisinin (D448360) dimer with anticancer and antiprotozoal activity.

Technology Process of Dihydro ArteMisinin DiMer

There total 3 articles about Dihydro ArteMisinin DiMer which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

1,2,3-trimethoxybenzene (621-23-8) + (5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl benzoate (163381-14-4) → 9,10-dehydrodihydroartemisinin (82596-30-3) + bis(3,6,9-trimethyl-3,12-epidioxy-3,4,5,5a,6,7,8,8a,9,10-decahydro-12H-pyrano[4,3-j][1,2]benzodioxepin-10-yl) ether (150358-71-7) + 10α-(2',4',6'-trimethoxyphenyl)-10-deoxo-10-dihydroartemisinin

Guidance literature:

With boron trifluoride diethyl etherate; In dichloromethane; at -30 ℃; for 1h;

DOI:10.1002/ejoc.200300064

Reference yield: 44.0%

dihydroartemisinin (71939-50-9) → bis(3,6,9-trimethyl-3,12-epidioxy-3,4,5,5a,6,7,8,8a,9,10-decahydro-12H-pyrano[4,3-j][1,2]benzodioxepin-10-yl) ether (150358-71-7)

Guidance literature:

With triethylamine; p-toluenesulfonyl chloride; In dichloromethane; at 20 ℃; for 24h;

DOI:10.1002/ejoc.200300064

Reference yield: 38.0%

10α-dihydroartemisinyl benzoate (82596-25-6) → 9,10-dehydrodihydroartemisinin (82596-30-3) + (5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl benzoate (163381-14-4) + bis(3,6,9-trimethyl-3,12-epidioxy-3,4,5,5a,6,7,8,8a,9,10-decahydro-12H-pyrano[4,3-j][1,2]benzodioxepin-10-yl) ether (150358-71-7)

Guidance literature:

With boron trifluoride diethyl etherate; In dichloromethane; at 0 ℃; for 1h;

DOI:10.1002/ejoc.200300064

upstream raw materials:

1,2,3-trimethoxybenzene

(5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl benzoate

dihydroartemisinin

10α-dihydroartemisinyl benzoate

Refernces