methyl 6-chloro-4-methoxypicolinate

Base Information

• Chemical Name: methyl 6-chloro-4-methoxypicolinate
• CAS No.: 204378-41-6
• Molecular Formula: C₈H₈ClNO₃
• Molecular Weight: 201.609
• Hs Code.: 2933399090
• Mol file: 204378-41-6.mol

Synonyms:6-Chloro-4-methoxypyridine-2-carboxylicacid methyl ester;

Chemical Property of methyl 6-chloro-4-methoxypicolinate

Chemical Property:

• Vapor Pressure: 0.000276mmHg at 25°C
• Refractive Index: 1.521
• Boiling Point: 322.6 °C at 760 mmHg
• PKA: -0.27±0.10(Predicted)
• Flash Point: 148.9 °C
• PSA: 48.42000
• Density: 1.288 g/cm³
• LogP: 1.53020
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

methyl6-chloro-4-methoxypicolinate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methyl 6-chloro-4-methoxypicolinate

There total 5 articles about methyl 6-chloro-4-methoxypicolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.3%

→ methyl 6-chloro-4-methoxypicolinate (204378-41-6)

Guidance literature:

Reference yield: 61.0%

4-methoxy-2-(methoxycarbonyl)pyridine 1-oxide (86251-47-0) → methyl 6-chloro-4-methoxypicolinate (204378-41-6)

Guidance literature:

With trichlorophosphate; at 100 ℃;

Reference yield: 61.0%

methanol (67-56-1) + methyl 4,6-dichloropyridine-2-carboxylate (98273-19-9) + sodium methylate (124-41-4) → methyl 6-chloro-4-methoxypicolinate (204378-41-6)

Guidance literature:

at 90 ℃; for 16h;

upstream raw materials:

methanol

methyl 4,6-dichloropyridine-2-carboxylate

sodium methylate

4,6-dichloro-2-pyridinecarboxylic acid

Downstream raw materials:

(S)-N-(3-(2-ethyl-4-(5-(4-methoxy-6-(pentan-3-yl)pyridin-2-yl)-1,2,4-oxadiazol-3-yl)-6-methylphenoxy)-2-hydroxypropyl)-2-hydroxyacetamide

4-methoxy-6-chloro picolinic acid

Refernces

• 1、 -. "CD38 INHIBITORS". Page/Page column 165-166. . Retrieved 2021/10/15.
• 2、 -. "N-(phenylsulfonyl)picolinamide derivatives, process for producing the same, and herbicide". . . Retrieved 2008/06/13.