6-CHLORO-4-METHOXY-PYRIDINE-2-CARBOXYLIC ACID

Base Information

• Chemical Name: 6-CHLORO-4-METHOXY-PYRIDINE-2-CARBOXYLIC ACID
• CAS No.: 88912-21-4
• Molecular Formula: C7H6ClNO3
• Molecular Weight: 187.583
• Hs Code.: 2933399090
• Mol file: 88912-21-4.mol

Synonyms:4-Methoxy-6-chloropicolinic acid

Chemical Property of 6-CHLORO-4-METHOXY-PYRIDINE-2-CARBOXYLIC ACID

Chemical Property:

• Vapor Pressure: 0.000276mmHg at 25°C
• Refractive Index: 1.521
• Boiling Point: 322.6 °C at 760 mmHg
• PKA: 3.15±0.10(Predicted)
• Flash Point: 148.9 °C
• PSA: 59.42000
• Density: 1.430g/cm³
• LogP: 1.44180
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

6-Chloro-4-methoxypicolinicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-CHLORO-4-METHOXY-PYRIDINE-2-CARBOXYLIC ACID

There total 3 articles about 6-CHLORO-4-METHOXY-PYRIDINE-2-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

methyl 6-chloro-4-methoxypicolinate (204378-41-6) → 4-methoxy-6-chloro picolinic acid (88912-21-4)

Guidance literature:

With lithium hydroxide monohydrate; water; In tetrahydrofuran; at 20 ℃; for 0.5h;

Reference yield:

4-methoxy-2-(methoxycarbonyl)pyridine 1-oxide (86251-47-0) → 4-methoxy-6-chloro picolinic acid (88912-21-4)

Guidance literature:

Multi-step reaction with 2 steps

1: trichlorophosphate / 100 °C

2: water; sodium hydroxide / tetrahydrofuran

With water; sodium hydroxide; trichlorophosphate; In tetrahydrofuran;

Reference yield:

methyl 4-methoxypicolinate (29681-43-4) → 4-methoxy-6-chloro picolinic acid (88912-21-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 3-chloro-benzenecarboperoxoic acid / ethyl acetate / 18 h / 20 °C

2: trichlorophosphate / 100 °C

3: water; sodium hydroxide / tetrahydrofuran

With water; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; ethyl acetate;

upstream raw materials:

methyl 6-chloro-4-methoxypicolinate

4-methoxy-2-(methoxycarbonyl)pyridine 1-oxide

methyl 4-methoxypicolinate

Downstream raw materials:

N-[(2-Chlorophenyl)sulfonyl]-6-chloro-4-methoxypyridine-2-carboxamide

N-[(2,6-Difluorophenyl)sulfonyl]-6-chloro-4-methoxy-2-pyridinecarboxamide

6-chloro-4-methoxypyridine-2-carboxylic acid amide

ethyl 6-chloro-4-methoxypicolinate

Refernces

• 1、 -. "CD38 INHIBITORS". Page/Page column 165-167. . Retrieved 2021/10/15.