IMIDAZO[1,2-A]PYRIDINE, 6-BROMO-2-(TRIFLUOROMETHYL)-

Base Information

• Chemical Name: IMIDAZO[1,2-A]PYRIDINE, 6-BROMO-2-(TRIFLUOROMETHYL)-
• CAS No.: 150780-40-8
• Molecular Formula: C₈H₄BrF₃N₂
• Molecular Weight: 265.032
• Hs Code.: 2933990090
• Mol file: 150780-40-8.mol

Synonyms:6-Bromo-2-trifluoromethylimidazo[1,2-a]pyridine

Chemical Property of IMIDAZO[1,2-A]PYRIDINE, 6-BROMO-2-(TRIFLUOROMETHYL)-

Chemical Property:

• Melting Point: 106-108oC
• PSA: 17.30000
• Density: 1.80
• LogP: 3.11560

Purity/Quality:

99%, ^*data from raw suppliers

6-Bromo-2-(trifluoromethyl)imidazo[1,2-a]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of IMIDAZO[1,2-A]PYRIDINE, 6-BROMO-2-(TRIFLUOROMETHYL)-

There total 1 articles about IMIDAZO[1,2-A]PYRIDINE, 6-BROMO-2-(TRIFLUOROMETHYL)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

5-bromo-2-pyridylamine (1072-97-5) + 3-bromo-1,1,1-trifluoroacetone (431-35-6) → 6-bromo-2-trifluoromethylimidazo[1,2-a]pyridine (150780-40-8)

Guidance literature:

5-bromo-2-pyridylamine; 3-bromo-1,1,1-trifluoroacetone; With potassium carbonate; In ethanol; for 24h; Heating / reflux;

With sodium hydrogencarbonate; In dichloromethane; water;

Reference yield: 11.4%

6-bromo-2-trifluoromethylimidazo[1,2-a]pyridine (150780-40-8) → 2-trifluoromethylimidazo[1,2-a]pyridine-6-boronic acid (869958-46-3)

Guidance literature:

6-bromo-2-trifluoromethylimidazo[1,2-a]pyridine; With n-butyllithium; Trimethyl borate; In diethyl ether; hexane; at -78 - -20 ℃; for 0.666667h;

With hydrogenchloride; water; In diethyl ether; hexane;

With sodium hydrogencarbonate; In water; pH=7;

Reference yield:

6-bromo-2-trifluoromethylimidazo[1,2-a]pyridine (150780-40-8) + 2-[2-(ethylsulfanyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolan → 6-(2-ethylsulfanylphenyl)-2-trifluoromethylimidazo[1,2-a]pyridine

Guidance literature:

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; at 110 ℃; for 7h;

upstream raw materials:

5-bromo-2-pyridylamine

3-bromo-1,1,1-trifluoroacetone

Downstream raw materials:

2-trifluoromethylimidazo[1,2-a]pyridine-6-boronic acid

6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethyl)imidazo[1,2-a]pyridine

Refernces

• 1、 -. "1-HETEROCYCLYL-1,5-DIHYDRO-PYRIDO[3,2-B]INDOL-2-ONES". Page/Page column 76. . Retrieved 2008/06/13.