Carbamic acid, N-(4-bromo-2-thiazolyl)-, 1,1-dimethylethyl ester

Base Information

• Chemical Name: Carbamic acid, N-(4-bromo-2-thiazolyl)-, 1,1-dimethylethyl ester
• CAS No.: 944804-88-0
• Molecular Formula: C8H11BrN2O2S
• Molecular Weight: 279.158
• Hs Code.: 2934100090
• Mol file: 944804-88-0.mol

Synonyms:tert-Butyl 4-bromothiazol-2-ylcarbamate;

Chemical Property of Carbamic acid, N-(4-bromo-2-thiazolyl)-, 1,1-dimethylethyl ester

Chemical Property:

• Refractive Index: 1.595
• PKA: 4.58±0.70(Predicted)
• PSA: 79.46000
• Density: 1.574 g/cm³
• LogP: 3.32560
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%Min ^*data from raw suppliers

tert-Butyl 4-bromothiazol-2-ylcarbamate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Carbamic acid, N-(4-bromo-2-thiazolyl)-, 1,1-dimethylethyl ester

There total 4 articles about Carbamic acid, N-(4-bromo-2-thiazolyl)-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tert-butyl 5-bromothiazol-2-ylcarbamate (405939-39-1) → tert-butyl N-(4-bromo-1,3-thiazol-2-yl)carbamate (944804-88-0)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; hexane; water; at 20 ℃; for 12.25h;

Reference yield: 80.0%

4-bromo-1,3-thiazol-2-amine (502145-18-8) + di-tert-butyl dicarbonate (24424-99-5) → tert-butyl N-(4-bromo-1,3-thiazol-2-yl)carbamate (944804-88-0)

Guidance literature:

With dmap; In dichloromethane; at 25 ℃; for 24h; Inert atmosphere;

DOI:10.1021/acs.joc.8b02655

Reference yield: 8.0%

tert-butyl carbazate (4248-19-5) + 2,4-dibromo-1,3-thiazole (4175-77-3) → tert-butyl N-(4-bromo-1,3-thiazol-2-yl)carbamate (944804-88-0)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 85 ℃; for 24h; Inert atmosphere;

upstream raw materials:

tert-butyl 5-bromothiazol-2-ylcarbamate

di-tert-butyl dicarbonate

4-bromo-1,3-thiazol-2-amine

tert-butyl carbazate

Refernces

• 1、 -. "NOVEL GALACTOSIDE INHIBITOR OF GALECTINS". Page/Page column 150-151. . Retrieved 2021/01/23.
• 2、 -. "VACCINE ADJUVANT". Page/Page column 71. . Retrieved 2020/06/10.