5-Methyl-2-pyrazinemethanol

Base Information

• Chemical Name: 5-Methyl-2-pyrazinemethanol
• CAS No.: 61892-95-3
• Molecular Formula: C6H8N2O
• Molecular Weight: 124.142
• Hs Code.: 2933990090
• Mol file: 61892-95-3.mol

Synonyms:Pyrazinemethanol, 5-methyl- (9CI);2-Hydroxymethyl-5-methylpyrazine;5-Methyl-2-pyrazinemethanol;5-Methyl-2-pyrazinylmethanol;5-Methylpyrazinemethanol;

Chemical Property of 5-Methyl-2-pyrazinemethanol

Chemical Property:

• Vapor Pressure: 0.0272mmHg at 25°C
• Melting Point: 47-48 °C
• Refractive Index: 1.549
• Boiling Point: 235.7 °C at 760 mmHg
• PKA: 12.77±0.10(Predicted)
• Flash Point: 96.3 °C
• PSA: 46.01000
• Density: 1.171 g/cm³
• LogP: 0.27730
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%Min ^*data from raw suppliers

(5-Methylpyrazin-2-yl)methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Methyl-2-pyrazinemethanol

There total 1 articles about 5-Methyl-2-pyrazinemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,2-diaminopropan (78-90-0,10424-38-1) + glycerol (56-81-5,25618-55-7,64333-26-2,8013-25-0) → 2,5-dimethyl-pyrazine (123-32-0) + 2-Hydroxymethyl-5-methylpyrazine (61892-95-3) + 2,6-dimethylpyrazine (108-50-9) + 2-hydroxymethyl-6-methylpyrazine (77164-93-3)

Guidance literature:

With water; at 380 ℃; Reagent/catalyst; regioselective reaction;

DOI:10.1016/j.cclet.2013.04.010

Reference yield: 93.0%

2-Hydroxymethyl-5-methylpyrazine (61892-95-3) → 2-methylpyrazin-5-carboxylic acid (5521-55-1)

Guidance literature:

With sodium hydroxide; at 40 ℃; Ni-anode, 12 mA/cm²;

DOI:10.1055/s-1990-26830

Reference yield: 86.0%

2-Hydroxymethyl-5-methylpyrazine (61892-95-3) + 3-chloro-4-fluoronitrobenzene (350-30-1) → 2-((2-chloro-4-nitrophenoxy)methyl)-5-methylpyrazine

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 12h;

upstream raw materials:

1,2-diaminopropan

glycerol

Downstream raw materials:

(5-methylpyrazin-2-yl)methyl 4-methylbenzenesulfonate

2,2-Dimethyl-6-[4-(4-phenyl-butyl)-phenoxy]-hexanoic acid 5-methyl-pyrazin-2-ylmethyl ester

2-methylpyrazin-5-carboxylic acid

2-methyl-5-pyrazinylmethyl chloride

Refernces