Imidazole-1-carbothioic acid O-{(2R,3R,5S)-2-(4-amino-2-oxo-2H-[1,3,5]triazin-1-yl)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester

Base Information

• Chemical Name: Imidazole-1-carbothioic acid O-{(2R,3R,5S)-2-(4-amino-2-oxo-2H-[1,3,5]triazin-1-yl)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester
• CAS No.: 107036-50-0
• Molecular Formula: C₃₃H₃₂N₆O₆S
• Molecular Weight: 640.72
• Mol file: 107036-50-0.mol

Synonyms:

Chemical Property of Imidazole-1-carbothioic acid O-{(2R,3R,5S)-2-(4-amino-2-oxo-2H-[1,3,5]triazin-1-yl)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Imidazole-1-carbothioic acid O-{(2R,3R,5S)-2-(4-amino-2-oxo-2H-[1,3,5]triazin-1-yl)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester

There total 4 articles about Imidazole-1-carbothioic acid O-{(2R,3R,5S)-2-(4-amino-2-oxo-2H-[1,3,5]triazin-1-yl)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4,4'-dimethoxytrityl chloride (40615-36-9) → Imidazole-1-carbothioic acid O-{(2R,3R,5S)-2-(4-amino-2-oxo-2H-[1,3,5]triazin-1-yl)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester (107036-50-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 59 percent / pyridine

2: 90 percent / acetonitrile

3: 1.) 4a,4a'-azoisobutyronitrile (AIBN), (n-Bu)3SnH / 1.) toluene, 110 to 120 deg C, 2 h, 2.) acetonitrile, 24 h

With pyridine; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In acetonitrile;

DOI:10.1021/jm00388a020

Reference yield:

5-azacytidine (320-67-2) → Imidazole-1-carbothioic acid O-{(2R,3R,5S)-2-(4-amino-2-oxo-2H-[1,3,5]triazin-1-yl)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester (107036-50-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 59 percent / pyridine

2: 90 percent / acetonitrile

3: 1.) 4a,4a'-azoisobutyronitrile (AIBN), (n-Bu)3SnH / 1.) toluene, 110 to 120 deg C, 2 h, 2.) acetonitrile, 24 h

With pyridine; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In acetonitrile;

DOI:10.1021/jm00388a020

Reference yield:

5'-O-(4,4'-dimethoxytrityl)-5-azacytidine (107036-45-3) → Imidazole-1-carbothioic acid O-{(2R,3R,5S)-2-(4-amino-2-oxo-2H-[1,3,5]triazin-1-yl)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester (107036-50-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / acetonitrile

2: 1.) 4a,4a'-azoisobutyronitrile (AIBN), (n-Bu)3SnH / 1.) toluene, 110 to 120 deg C, 2 h, 2.) acetonitrile, 24 h

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In acetonitrile;

DOI:10.1021/jm00388a020

upstream raw materials:

1,1'-Thiocarbonyldiimidazole

5'-O-(4,4'-dimethoxytrityl)-5-azacytidine 2',3'-O-(cyclic thiocarbonate)

4,4'-dimethoxytrityl chloride

5-azacytidine

Refernces