3-Bromo-5-(3-chlorophenoxy)pyridine

Base Information

• Chemical Name: 3-Bromo-5-(3-chlorophenoxy)pyridine
• CAS No.: 28232-65-7
• Molecular Formula: C₁₁H₇BrClNO
• Molecular Weight: 284.54
• Hs Code.: 2933399090
• Mol file: 28232-65-7.mol

Synonyms:Pyridine,3-bromo-5-(m-chlorophenoxy)- (8CI);3-bromo-5-(3-chlorophenoxy)pyridine;Pyridine, 3-bromo-5-(3-chlorophenoxy)-;

Chemical Property of 3-Bromo-5-(3-chlorophenoxy)pyridine

Chemical Property:

• Refractive Index: 1.616
• Boiling Point: 342.092 °C at 760 mmHg
• Flash Point: 160.691 °C
• PSA: 22.12000
• Density: 1.569 g/cm³
• LogP: 4.28980
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

3-Bromo-5-(3-chlorophenoxy)pyridine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Bromo-5-(3-chlorophenoxy)pyridine

There total 3 articles about 3-Bromo-5-(3-chlorophenoxy)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-monochlorophenol (108-43-0) + 3-bromo-5-isopropoxypyridine (212332-40-6) → 3-bromo-5-(3-chlorophenoxy)pyridine (28232-65-7)

Guidance literature:

3-monochlorophenol; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 3h; Cooling with ice;

3-bromo-5-isopropoxypyridine; In N,N-dimethyl-formamide; mineral oil; at 100 ℃; for 48h;

DOI:10.1021/jm3011299

Reference yield:

3,5-dibromopyridine (625-92-3) → 3-bromo-5-(3-chlorophenoxy)pyridine (28232-65-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium; copper / isopropyl alcohol / 14 h / 140 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 3 h / 0 - 20 °C / Cooling with ice

2.2: 48 h / 100 °C

With potassium; copper; sodium hydride; In N,N-dimethyl-formamide; isopropyl alcohol; mineral oil;

DOI:10.1021/jm3011299

Reference yield:

→ 3-bromo-5-(3-chlorophenoxy)pyridine (28232-65-7)

Guidance literature:

3,5-Dibrompyridin, 3-Chlorkaliumphenolat, Cu;

upstream raw materials:

3,5-dibromopyridine

3-monochlorophenol

3-bromo-5-isopropoxypyridine

Refernces

• 1、 Breining, Scott R.,Melvin, Matt,Bhatti, Balwinder S.,Byrd, Gary D.,Kiser, Melanie N.,Hepler, Christopher D.,Hooker, Dawn N.,Zhang, Jenny,Reynolds, Leslie A.,Benson, Lisa R.,Fedorov, Nikolai B.,Sidach, Serguei S.,Mitchener, J. Pike,Lucero, Linda M.,Lukas, Ronald J.,Whiteaker, Paul,Yohannes, Daniel. "Structure-activity studies of 7-heteroaryl-3-azabicyclo[3.3.1]non-6-enes: A novel class of highly potent nicotinic receptor ligands". . p. 9929 - 9945. Retrieved 2013/01/16.