cefsulodin sodium

Base Information

• Chemical Name: cefsulodin sodium
• CAS No.: 41444-66-0
• Molecular Formula: C₂₂H₁₉N₄O₈S₂*Na
• Molecular Weight: 554.537
• Mol file: 41444-66-0.mol

Synonyms:Pyridinium, 4-(aminocarbonyl)-1-[[2-carboxy-8-oxo-7-[(phenylsulfoacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-, inner salt, monosodium salt, [6R-(6α,7β)]-;[6R-(6a,7b)]-4-(Aminocarbonyl)-1-[[2-carboxy-8-oxo-7-[(phenylsulfoacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]pyridinium inner salt monosodium salt;Cefsulodin sodium

Chemical Property of cefsulodin sodium

Chemical Property:

• PSA: 227.39000
• LogP: -0.12670

Purity/Quality:

98%Min ^*data from raw suppliers

Cefsulodin sodium ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Antibacterial.

Technology Process of cefsulodin sodium

There total 5 articles about cefsulodin sodium which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

cefsulodin (62587-73-9) → Cefomonil (41444-66-0,52152-93-9,52152-94-0)

Guidance literature:

With sodium acetate; In ethanol; water; pH=4 - 4.25; Product distribution / selectivity;

Reference yield: 85.0%

cefsulodin → cefsulodin sodium salt (41444-66-0,52152-93-9,52152-94-0)

Guidance literature:

With sodium acetate; In ethanol; water; at 0 - 5 ℃; pH=~ 4.0 - ~ 4.25; Product distribution / selectivity;

Reference yield:

7-Aminocephalosporanic acid (957-68-6) → Cefomonil (41444-66-0,52152-93-9,52152-94-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 1,1,1,3,3,3-hexamethyl-disilazane; sulfuric acid / dichloromethane / 4 h / Reflux; Large scale

1.2: Large scale

2.1: sodium hydrogencarbonate / dichloromethane; water / 1 h / 0 - 5 °C / Large scale

3.1: sodium acetate; pyrographite / water / pH 4.1 / Large scale

With sulfuric acid; sodium acetate; sodium hydrogencarbonate; pyrographite; 1,1,1,3,3,3-hexamethyl-disilazane; In dichloromethane; water;

upstream raw materials:

cefsulodin

7-Aminocephalosporanic acid

isonicotinamide

2-phenyl-2-sulfoacetic acid

Refernces

• 1、 -. "PROCESS FOR PREPARING CEFSULODIN SODIUM". Page/Page column 7. . Retrieved 2010/05/13.