Technology Process of di-t-butyl 5-trifluoromethyl-5,8-dideazafolate
There total 7 articles about di-t-butyl 5-trifluoromethyl-5,8-dideazafolate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 34 percent / dimethylformamide / 35 h / Heating
2: 61 percent / 98 percent sulfuric acid, 90 percent nitric acid / 1) 0 deg C, 30 min; 2) RT, 24 h
3: 69 percent / H2 / 10 percent palladium charcoal / dimethylformamide; 2-methoxy-ethanol / 0.5 h / 2327.2 Torr
4: 1) 2N aq. hydrochloric acid, sodium nitrite; 2) CuCl / 1) 2 deg C, 20 min; 2) H2O, 2 deg C, 30 min, then 35 deg C, 30 min, then RT, 1 h
5: 70 percent acetic acid, H2 / Raney nickel / Ambient temperature
With
hydrogenchloride; sulfuric acid; hydrogen; nitric acid; acetic acid; N,N-dimethyl-formamide; copper(l) chloride; sodium nitrite;
palladium on activated charcoal; nickel;
In
2-methoxy-ethanol; N,N-dimethyl-formamide;
DOI:10.1002/jhet.5570270746
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 48 percent / monoperphthalic acid / diethyl ether; tetrahydrofuran / 5 h / 0 °C
2: 34 percent / dimethylformamide / 35 h / Heating
3: 61 percent / 98 percent sulfuric acid, 90 percent nitric acid / 1) 0 deg C, 30 min; 2) RT, 24 h
4: 69 percent / H2 / 10 percent palladium charcoal / dimethylformamide; 2-methoxy-ethanol / 0.5 h / 2327.2 Torr
5: 1) 2N aq. hydrochloric acid, sodium nitrite; 2) CuCl / 1) 2 deg C, 20 min; 2) H2O, 2 deg C, 30 min, then 35 deg C, 30 min, then RT, 1 h
6: 70 percent acetic acid, H2 / Raney nickel / Ambient temperature
With
hydrogenchloride; monoperoxyphthalic acid; sulfuric acid; hydrogen; nitric acid; acetic acid; N,N-dimethyl-formamide; copper(l) chloride; sodium nitrite;
palladium on activated charcoal; nickel;
In
tetrahydrofuran; diethyl ether; 2-methoxy-ethanol; N,N-dimethyl-formamide;
DOI:10.1002/jhet.5570270746
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 98 percent / dimethylacetamide / 5 h / 128 - 130 °C
2: 94 percent / 1N aq. sodium hydroxide / 5 h / Heating
3: 61 percent / 98 percent sulfuric acid, 90 percent nitric acid / 1) 0 deg C, 30 min; 2) RT, 24 h
4: 69 percent / H2 / 10 percent palladium charcoal / dimethylformamide; 2-methoxy-ethanol / 0.5 h / 2327.2 Torr
5: 1) 2N aq. hydrochloric acid, sodium nitrite; 2) CuCl / 1) 2 deg C, 20 min; 2) H2O, 2 deg C, 30 min, then 35 deg C, 30 min, then RT, 1 h
6: 70 percent acetic acid, H2 / Raney nickel / Ambient temperature
With
hydrogenchloride; sodium hydroxide; ISOPROPYLAMIDE; sulfuric acid; hydrogen; nitric acid; acetic acid; copper(l) chloride; sodium nitrite;
palladium on activated charcoal; nickel;
In
2-methoxy-ethanol; N,N-dimethyl-formamide;
DOI:10.1002/jhet.5570270746
