J&J Ex-61

Base Information

• Chemical Name: J&J Ex-61
• CAS No.: 943540-75-8
• Molecular Formula: C₁₉H₁₃F₂N₇
• Molecular Weight: 377.356
• Hs Code.: 2933990090
• Mol file: 943540-75-8.mol

Synonyms:J&J Ex-61;Quinoline, 6-[difluoro[6-(1-methyl-1H-pyrazol-4-yl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]methyl]-;6-[Difluoro[6-(1-methyl-1H-pyrazol-4-yl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]methyl]quinoline;JNJ-38877605;JNJ-33877605;6-[Difluoro[6-(1-methyl-1H-pyrazol-4-yl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]methyl]quinoline JNJ 38877605;JNJ 38877605 6-[Difluoro[6-(1-methyl-1H-pyrazol-4-yl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]methyl]quinoline

Chemical Property of J&J Ex-61

Chemical Property:

• Refractive Index: 1.733
• PSA: 73.79000
• Density: 1.50 g/cm³
• LogP: 3.21310
• Solubility.: insoluble in H2O; ≥18.85 mg/mL in DMSO; ≥3.25 mg/mL in EtOH with ultrasonic

Purity/Quality:

98% min ^*data from raw suppliers

JNJ-38877605 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: JNJ-38877605 is a potent inhibitor of c-Met catalytic activity. Selective over other tyrosine and serine-threonine kinases (600-fold selectivity). Ability to block constitutive or HGF-stimulated phosphorylation of c-Met demonstrated in vitro. JNJ 38877605 reduces radiation-induced invasion, apoptosis and proliferation of cancer cells in vitro.

Technology Process of J&J Ex-61

There total 10 articles about J&J Ex-61 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

3-chloro-6-(1-methyl-1H-pyrazol-4-yl)pyridazine (943541-20-6) + 2,2-difluoro-2-(quinolin-6-yl)acetic acid hydrazide (943541-39-7) → JNJ-38877605 (943540-75-8)

Guidance literature:

3-chloro-6-(1-methyl-1H-pyrazol-4-yl)pyridazine; 2,2-difluoro-2-(quinolin-6-yl)acetic acid hydrazide; With methanesulfonic acid; In 1-methoxy-2-propanol; at 80 ℃; for 8h;

With ammonia; In ethanol; water; at 80 ℃;

Reference yield: 51.0%

6-{1,1-difluoro-2-[(6E)-6-hydrazono-3-(1-methyl-1H-pyrazol-4-yl)pyridazin-1(6H)-yl]-2-oxoethyl}quinoline → JNJ-38877605 (943540-75-8)

Guidance literature:

6-{1,1-difluoro-2-[(6E)-6-hydrazono-3-(1-methyl-1H-pyrazol-4-yl)pyridazin-1(6H)-yl]-2-oxoethyl}quinoline; In 1-methoxy-2-propanol; at 105 - 108 ℃; for 2h; Heating / reflux;

With water; sodium carbonate; In 1-methoxy-2-propanol; at 20 ℃; Product distribution / selectivity;

Reference yield:

ethyl 2,2-difluoro-2-(quinolin-6-yl)acetate (943541-40-0) → JNJ-38877605 (943540-75-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrazine / tert-Amyl alcohol / 20 °C

2.1: methanesulfonic acid / 1-methoxy-2-propanol / 8 h / 80 °C

2.2: 80 °C

With methanesulfonic acid; hydrazine; In tert-Amyl alcohol; 1-methoxy-2-propanol;

upstream raw materials:

3-chloro-6-(1-methyl-1H-pyrazol-4-yl)pyridazine

2,2-difluoro-2-(quinolin-6-yl)acetic acid hydrazide

6-bromoquinoline

6-iodoquinoline

Refernces

• 1、 -. "TRIAZOLOPYRIDAZINES AS TYROSINE KINASE MODULATORS". Page/Page column 117; 119-120. . Retrieved 2008/06/13.