2,3-Dihydro-alpha-hydroxy-5-benzofuranacetic acid

Base Information

• Chemical Name: 2,3-Dihydro-alpha-hydroxy-5-benzofuranacetic acid
• CAS No.: 69999-15-1
• Molecular Formula: C₁₀H₁₀O₄
• Molecular Weight: 194.187
• Hs Code.: 2932999099
• Mol file: 69999-15-1.mol

Synonyms:2,3-Dihydro-alpha-hydroxy-5-benzofuranacetic acid;

Chemical Property of 2,3-Dihydro-alpha-hydroxy-5-benzofuranacetic acid

Chemical Property:

• Boiling Point: 407.2 °C at 760 mmHg
• PKA: 3.53±0.11(Predicted)
• Flash Point: 168.2 °C
• PSA: 66.76000
• Density: 1.435 g/cm³
• LogP: 0.73950
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

2-(2,3-Dihydrobenzofuran-5-yl)-2-hydroxyaceticacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,3-Dihydro-alpha-hydroxy-5-benzofuranacetic acid

There total 3 articles about 2,3-Dihydro-alpha-hydroxy-5-benzofuranacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

2-(2,3-dihydro-5-benzofuranyl)glycine (71922-83-3) → 2-(2,3-dihydro-5-benzofuranyl)-2-hydroxyacetic acid (69999-15-1)

Guidance literature:

With sodium nitrite; In water; acetic acid;

Reference yield:

2.3-dihydrobenzofuran (496-16-2) → 2-(2,3-dihydro-5-benzofuranyl)-2-hydroxyacetic acid (69999-15-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 11.75 g / conc. H₂SO₄ / acetic acid / 0.5 h / Ambient temperature

2: 60 percent / H₂ / 10percent Pd/C / methanol; H₂O / 4 h / 2068.6 Torr

3: aq. NaNO₂, AcOH / 4 h / 65 °C

With sulfuric acid; hydrogen; acetic acid; sodium nitrite; palladium on activated charcoal; In methanol; water; acetic acid;

DOI:10.1021/jm00178a011

Reference yield:

Dl-α-benzyloxycarbonylamino-2,3-dihydro-5-benzo(b)furanyl acetic acid (79002-44-1) → 2-(2,3-dihydro-5-benzofuranyl)-2-hydroxyacetic acid (69999-15-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 60 percent / H₂ / 10percent Pd/C / methanol; H₂O / 4 h / 2068.6 Torr

2: aq. NaNO₂, AcOH / 4 h / 65 °C

With hydrogen; acetic acid; sodium nitrite; palladium on activated charcoal; In methanol; water;

DOI:10.1021/jm00178a011

upstream raw materials:

2-(2,3-dihydro-5-benzofuranyl)glycine

2.3-dihydrobenzofuran

Dl-α-benzyloxycarbonylamino-2,3-dihydro-5-benzo(b)furanyl acetic acid

Refernces

• 1、 Boehme, E. H. W.,Bambury, R. E.,Baumann, R. J.,Erickson, R. C.,Harrison, B. L.,et al.. "Orally Active Cephalosporins and Penicillins". . p. 405 - 412. Retrieved 2007/10/02.