4-PIPERIDIN-4-YL-BENZOIC ACID METHYL ESTER HCL

Base Information

• Chemical Name: 4-PIPERIDIN-4-YL-BENZOIC ACID METHYL ESTER HCL
• CAS No.: 936130-82-4
• Molecular Formula: C13H17NO2^.HCl
• Molecular Weight: 255.744
• Hs Code.: 2933399990
• Mol file: 936130-82-4.mol

Synonyms:4-PIPERIDIN-4-YL-BENZOIC ACID METHYL ESTER HCL;4-(4-METHOXYCARBONYLPHENYL) PIPERIDINE HYDROCHLORIDE;METHYL 4-(PIPERIDIN-4-YL)BENZOATE HYDROCHLORIDE;Methyl 4-(4-piperidyl)benzoate hydrochloride;4-Piperidin-4-yl-benzoic acid methyl ester hydrochloride;Benzoic acid, 4-(4-piperidinyl)-, Methyl ester, hydrochloride

Chemical Property of 4-PIPERIDIN-4-YL-BENZOIC ACID METHYL ESTER HCL

Chemical Property:

• Boiling Point: 371.4 °C at 760 mmHg
• Flash Point: 178.4 °C
• PSA: 38.33000
• LogP: 3.07100
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

95-99% ^*data from raw suppliers

4-Piperidin-4-yl-benzoicacidmethylesterhydrochloride 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-PIPERIDIN-4-YL-BENZOIC ACID METHYL ESTER HCL

There total 5 articles about 4-PIPERIDIN-4-YL-BENZOIC ACID METHYL ESTER HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-Pyridin-4-yl-benzoic acid methyl ester (106047-17-0) → methyl 4-(piperidine-4-yl)benzoate hydrochloride (936130-82-4)

Guidance literature:

With hydrogenchloride; platinum(IV) oxide; hydrogen; In methanol; water; at 50 ℃; for 16h; under 2585.81 Torr;

Reference yield:

4-(4-methoxycarbonyl-phenyl)-piperidine-1-carboxylic acid tert-butyl ester (355379-05-4) → methyl 4-(piperidine-4-yl)benzoate hydrochloride (936130-82-4)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane;

Reference yield:

4-methoxycarbonylphenylboronic acid (99768-12-4) → methyl 4-(piperidine-4-yl)benzoate hydrochloride (936130-82-4)

Guidance literature:

Multi-step reaction with 2 steps

1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / 1,2-dimethoxyethane / 10 h / 90 °C / Inert atmosphere

2: platinum(IV) oxide; hydrogenchloride; hydrogen / methanol; water / 16 h / 50 °C / 2585.81 Torr / Inert atmosphere

With hydrogenchloride; platinum(IV) oxide; bis-triphenylphosphine-palladium(II) chloride; hydrogen; sodium carbonate; In methanol; 1,2-dimethoxyethane; water;

upstream raw materials:

4-(4-methoxycarbonyl-phenyl)-piperidine-1-carboxylic acid tert-butyl ester

4-bromopyridin

4-methoxycarbonylphenylboronic acid

4-Pyridin-4-yl-benzoic acid methyl ester

Downstream raw materials:

methyl 4-[1-[4-methyl-3-(pyridine-4-carbonylamino)benzoyl]-4-piperidyl]benzoate

(2S,3R)-3-hydroxy-2-(4-(1-(4-morpholin-4-ylmethylphenyl)piperidin-4-yl)benzoylamino)butyric acid methyl ester

4-(1-(4-morpholin-4-ylmethylphenyl)piperidin-4-yl)benzoic acid methyl ester

C₃₂H₃₂N₄O₂

Refernces

• 1、 -. "Pyrrolo pyrimidine ring compound, its use and pharmaceutical composition (by machine translation)". Page/Page column 50; 51. . Retrieved 2017/07/31.