355379-05-4

Basic information

• Product Name: 4-(4-methoxycarbonyl-phenyl)-piperidine-1-carboxylic acid tert-butyl ester
• Synonyms: 4-(4-methoxycarbonyl-phenyl)-piperidine-1-carboxylic acid tert-butyl ester
• CAS NO: 355379-05-4
• Molecular Weight: 319.401
• Mol File: 355379-05-4.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 426.4±45.0 °C(Predicted)
• Density: 1.113±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 4-(4-methoxycarbonyl-phenyl)-piperidine-1-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-methoxycarbonyl-phenyl)-piperidine-1-carboxylic acid tert-butyl ester(355379-05-4)
• EPA Substance Registry System: 4-(4-methoxycarbonyl-phenyl)-piperidine-1-carboxylic acid tert-butyl ester(355379-05-4)

Safety Data

• Hazardous Substances Data: 355379-05-4(Hazardous Substances Data)

Upstream product

• 619-42-1 4-methoxycarbonylphenyl bromide 
• 375853-82-0 tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate 
• 619-44-3 methyl 4-iodobenzoate 
• 106047-17-0 4-Pyridin-4-yl-benzoic acid methyl ester 
• 99768-12-4 4-methoxycarbonylphenylboronic acid 
• 1120-87-2 4-bromopyridin 
• 281235-04-9 methyl 4-(piperidine-4-yl)benzoate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 17763-71-2 4-carbomethoxyphenyl triflate 
• 180695-79-8 tert-butyl 4-bromo-1-piperidinecarboxylate 
• 301673-14-3 tert-butyl 4-iodopiperidine-1-carboxylate 
• 109384-19-2 t-butyl 4-hydroxy piperidine-1-carboxylate 
• 936130-82-4 methyl 4-(piperidine-4-yl)benzoate hydrochloride 

Downstream Products

• 149353-75-3 4-(1-(tert-butoxycarbonyl)piperidin-4-yl)benzoic acid 
• 936130-82-4 methyl 4-(piperidine-4-yl)benzoate hydrochloride 

Relevant articles and documents

Chimeric compound for targeted degradation of androgen receptor protein, preparation method of chimeric compound and application of chimeric compound in medicine

The invention relates to a chimera compound for targeted degradation of androgen receptor protein, a preparation method of the chimera compound and application of the chimera compound in medicine. Specifically, the invention relates to a chimera (PROTAC) compound for targeted degradation of AR protein of a fused heterocyclic cerebellar protein (cerebellone) E3 ubiquitin ligase ligand as shown in a general formula (IM), a preparation method of the chimera compound, and application of the chimera compound in medicine, and particularly relates to a chimera (PROTAC) compound for targeted degradation of AR protein of a fused heterocyclic cerebellar protein E3 ubiquitin ligase ligand of a fused heterocyclic cerebellar protein E3 ubiquitin ligase ligand.

Practical synthesis of pharmaceutically relevant molecules enriched in sp3 character

The expedient synthesis of compounds enriched in sp3 character is key goal in modern drug discovery. Herein, we report how a single pot Suzuki-Miyaura-hydrogenation can be used to furnish lead and fragment-like products in good to excellent yields. The approach has been successfully applied in formats amenable to parallel synthesis, in an asymmetric sense, and in the preparation of molecules with annotated biological activity.

Pyrrolo pyrimidine ring compound, its use and pharmaceutical composition (by machine translation)

The invention relates to an as TLR7 agonist of the pyrrolo pyrimidine compounds, specifically on a compound of formula (I) compound or its pharmaceutically acceptable salt, preparation method thereof, containing the compounds of the pharmaceutical composition, and its use for the preparation of antiviral drug use. Formula (I) (by machine translation)