17763-71-2

Basic information

• Product Name: Benzoic acid, 4-[[(trifluoromethyl)sulfonyl]oxy]-, methyl ester
• CAS NO: 17763-71-2
• Molecular Formula: C9H7F3O5S
• Molecular Weight: 284.213
• Mol File: 17763-71-2.mol
• Article Data: 27

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 4-[[(trifluoromethyl)sulfonyl]oxy]-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-[[(trifluoromethyl)sulfonyl]oxy]-, methyl ester(17763-71-2)
• EPA Substance Registry System: Benzoic acid, 4-[[(trifluoromethyl)sulfonyl]oxy]-, methyl ester(17763-71-2)

Safety Data

• Hazardous Substances Data: 17763-71-2(Hazardous Substances Data)

Upstream product

• 99-76-3 methyl 4-hydroxylbenzoate 
• 1493-13-6 trifluorormethanesulfonic acid 
• 99768-12-4 4-methoxycarbonylphenylboronic acid 
• 110-86-1 pyridine 
• 335-05-7 Trifluoromethanesulfonyl fluoride 
• 121-44-8 triethylamine 
• 99-96-7 4-hydroxy-benzoic acid 
• 407-25-0 trifluoroacetic anhydride 
• 358-23-6 trifluoromethylsulfonic anhydride 

Downstream Products

• 720-75-2 methyl 4-phenylbenzoate 
• 1571-08-0 methyl 4-formylbenzoate 
• 106047-17-0 4-Pyridin-4-yl-benzoic acid methyl ester 
• 93-58-3 benzoic acid methyl ester 
• 792-74-5 4,4'-biphenyldicarboxylic acid dimethyl ester 
• 99-76-3 methyl 4-hydroxylbenzoate 
• 4058-18-8 methyl 4-(phenylamino)benzoate 
• 14518-67-3 methyl 4-(phenylethyl)benzoate 
• 129488-73-9 methyl 4-(1-cyano-1-methylethyl)-benzoate 
• 403-33-8 methyl 4-flurobenzoate 
• 4906-25-6 methyl 4-butyloxybenzoate 
• 1679-64-7 Monomethyl terephthalate 
• 2550-40-5 1,2-dicyclohexyl disulfide 

Relevant articles and documents

Ni-Catalyzed Cross-Electrophile Coupling of Aryl Triflates with Thiocarbonates via C-O/C-O Bond Cleavage

A nickel-catalyzed reductive coupling of aryl triflates with thiocarbonates is reported here. Both electron-rich and -deficient aryl C(sp2)-O electrophiles as well as a class of O-tBu S-alkyl thiocarbonates are compatible with the optimized reaction conditions, as evidenced by 49 examples. The reaction also proceeds with good chemoselective cleavage of the C-O bond with regard to thioesters. This work broadens the scope of nickel-catalyzed reductive cross-electrophile coupling reactions.

Palladium-Catalyzed Chlorocarbonylation of Aryl (Pseudo)Halides Through In Situ Generation of Carbon Monoxide

An efficient palladium-catalyzed chlorocarbonylation of aryl (pseudo)halides that gives access to a wide range of carboxylic acid derivatives has been developed. The use of butyryl chloride as a combined CO and Cl source eludes the need for toxic, gaseous carbon monoxide, thus facilitating the synthesis of high-value products from readily available aryl (pseudo)halides. The combination of palladium(0), Xantphos, and an amine base is essential to promote this broadly applicable catalytic reaction. Overall, this reaction provides access to a great variety of carbonyl-containing products through in situ transformation of the generated aroyl chloride. Combined experimental and computational studies support a reaction mechanism involving in situ generation of CO.

Electrochemically Enabled, Nickel-Catalyzed Amination

Along with amide bond formation, Suzuki cross-coupling, and reductive amination, the Buchwald–Hartwig–Ullmann-type amination of aryl halides stands as one of the most employed reactions in modern medicinal chemistry. The work herein demonstrates the potential of utilizing electrochemistry to provide a complementary avenue to access such critical bonds using an inexpensive nickel catalyst under mild reaction conditions. Of note is the scalability, functional-group tolerance, rapid rate, and the ability to employ a variety of aryl donors (Ar?Cl, Ar?Br, Ar?I, Ar?OTf), amine types (primary and secondary), and even alternative X?H donors (alcohols and amides).