Technology Process of N-<(1-methoxycarbonyl-3-methylbutyl)carbamoyl>-L-valyl-L-alanyl-α-aza-alanine benzyl ester
There total 4 articles about N-<(1-methoxycarbonyl-3-methylbutyl)carbamoyl>-L-valyl-L-alanyl-α-aza-alanine benzyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) N-methylmorpholine, ethyl chloroformate, 2.) N-methylmorpholine / 1.) DMF, -20 deg C, 2 min,2.) DMF, -20 deg C, then 0 deg C, 2 h, then overnight, room temperature
2: HCl / ethyl acetate
3: triethylamine / CHCl3 / 1.) 2 h, 2.) room temperature, overnight
With
4-methyl-morpholine; hydrogenchloride; chloroformic acid ethyl ester; triethylamine;
In
chloroform; ethyl acetate;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) N-methylmorpholine, ethyl chloroformate, 2.) N-methylmorpholine / 1.) DMF, -20 deg C, 2 min,2.) DMF, -20 deg C, then 0 deg C, 2 h, then overnight, room temperature
2: HCl / ethyl acetate
3: triethylamine / CHCl3 / 1.) 2 h, 2.) room temperature, overnight
With
4-methyl-morpholine; hydrogenchloride; chloroformic acid ethyl ester; triethylamine;
In
chloroform; ethyl acetate;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: HCl / ethyl acetate
2: triethylamine / CHCl3 / 1.) 2 h, 2.) room temperature, overnight
With
hydrogenchloride; triethylamine;
In
chloroform; ethyl acetate;