Technology Process of 3-{(1Z,4Z,9Z,15Z)-7,12-Bis-(1-methoxy-ethyl)-3,8,13,17-tetramethyl-18-[2-(2,4,5-trimethyl-3,6-dioxo-cyclohexa-1,4-dienylmethoxycarbonyl)-ethyl]-porphyrin-2-yl}-propionic acid 2,4,5-trimethyl-3,6-dioxo-cyclohexa-1,4-dienylmethyl ester
There total 3 articles about 3-{(1Z,4Z,9Z,15Z)-7,12-Bis-(1-methoxy-ethyl)-3,8,13,17-tetramethyl-18-[2-(2,4,5-trimethyl-3,6-dioxo-cyclohexa-1,4-dienylmethoxycarbonyl)-ethyl]-porphyrin-2-yl}-propionic acid 2,4,5-trimethyl-3,6-dioxo-cyclohexa-1,4-dienylmethyl ester which
guide to synthetic route it.
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synthetic route:
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142230-12-4
3-{(1Z,4Z,9Z,15Z)-7,12-Bis-(1-methoxy-ethyl)-3,8,13,17-tetramethyl-18-[2-(2,4,5-trimethyl-3,6-dioxo-cyclohexa-1,4-dienylmethoxycarbonyl)-ethyl]-porphyrin-2-yl}-propionic acid 2,4,5-trimethyl-3,6-dioxo-cyclohexa-1,4-dienylmethyl ester
- Guidance literature:
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Multi-step reaction with 4 steps
1: aq. HBr (d 1.45) / acetic acid / 72 h
2: 12 h / 20 °C
3: 94 percent / aq. NaOH / dioxane / 1 h / 70 °C
4: 33.8 percent / di-tert-butyl pyrocarbonate, pyridine, 4-dimethylaminopyridine / CHCl3 / 0.5 h / 20 °C
With
pyridine; dmap; sodium hydroxide; di-tert-butyl dicarbonate; hydrogen bromide;
In
1,4-dioxane; chloroform; acetic acid;
DOI:10.1007/BF00486797
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142230-12-4
3-{(1Z,4Z,9Z,15Z)-7,12-Bis-(1-methoxy-ethyl)-3,8,13,17-tetramethyl-18-[2-(2,4,5-trimethyl-3,6-dioxo-cyclohexa-1,4-dienylmethoxycarbonyl)-ethyl]-porphyrin-2-yl}-propionic acid 2,4,5-trimethyl-3,6-dioxo-cyclohexa-1,4-dienylmethyl ester
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 12 h / 20 °C
2: 94 percent / aq. NaOH / dioxane / 1 h / 70 °C
3: 33.8 percent / di-tert-butyl pyrocarbonate, pyridine, 4-dimethylaminopyridine / CHCl3 / 0.5 h / 20 °C
With
pyridine; dmap; sodium hydroxide; di-tert-butyl dicarbonate;
In
1,4-dioxane; chloroform;
DOI:10.1007/BF00486797
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-
142230-12-4
3-{(1Z,4Z,9Z,15Z)-7,12-Bis-(1-methoxy-ethyl)-3,8,13,17-tetramethyl-18-[2-(2,4,5-trimethyl-3,6-dioxo-cyclohexa-1,4-dienylmethoxycarbonyl)-ethyl]-porphyrin-2-yl}-propionic acid 2,4,5-trimethyl-3,6-dioxo-cyclohexa-1,4-dienylmethyl ester
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 94 percent / aq. NaOH / dioxane / 1 h / 70 °C
2: 33.8 percent / di-tert-butyl pyrocarbonate, pyridine, 4-dimethylaminopyridine / CHCl3 / 0.5 h / 20 °C
With
pyridine; dmap; sodium hydroxide; di-tert-butyl dicarbonate;
In
1,4-dioxane; chloroform;
DOI:10.1007/BF00486797