protoporphyrin

Base Information

• Chemical Name: protoporphyrin
• CAS No.: 51589-12-9
• Molecular Formula: C₃₈H₄₆N₄O₆
• Molecular Weight: 654.806
• Mol file: 51589-12-9.mol

Synonyms:

Chemical Property of protoporphyrin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of protoporphyrin

There total 5 articles about protoporphyrin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) → mesoporphyrin IX dimethyl ester (1263-63-4) + protoporphyrin (51589-12-9,143028-39-1,143028-40-4)

Guidance literature:

With sodium hydroxide; sodium tetrahydroborate; oxygen; cetyltrimethylammonim bromide; oxalic acid; Yield given. Multistep reaction. Yields of byproduct given; 1) sodium phosphate buffer (pH 8.1), 3 min;;

DOI:10.1039/P19810002864

Reference yield:

methanol (67-56-1) + hematoporphyrin (14459-29-1) → hematoporphyrin-dimethyl ester (32562-61-1,119366-88-0,119366-89-1,131070-54-7,131070-74-1,6033-09-6) + protoporphyrin (51589-12-9,143028-39-1,143028-40-4)

Guidance literature:

sulfuric acid; for 0.75h; Product distribution; Ambient temperature; in the presence of trimethyl orthoformate, water;

DOI:10.1016/S0040-4039(00)80313-5

Reference yield:

methanol (67-56-1) + protoporphyrin IX dimethyl ester (5522-66-7,6164-53-0) → dimethyl 3,8-bis(1-methoxyethyl)-2,7,12,18-tetramethylporphyrin-13,17dipropanoate (51589-12-9) + 3-{(5Z,10Z,14Z,19Z)-18-(2-Methoxycarbonyl-ethyl)-12-(1-methoxy-ethyl)-7-[1-(4-methoxy-phenyl)-ethyl]-3,8,13,17-tetramethyl-porphyrin-2-yl}-propionic acid methyl ester (140411-00-3) + 3-{(5Z,10Z,14Z,19Z)-18-(2-Methoxycarbonyl-ethyl)-12-(1-methoxy-ethyl)-7-[1-(2-methoxy-phenyl)-ethyl]-3,8,13,17-tetramethyl-porphyrin-2-yl}-propionic acid methyl ester (140411-02-5) + 3-{(1Z,5Z,9Z,14Z)-18-(2-Methoxycarbonyl-ethyl)-13-(1-methoxy-ethyl)-8-[1-(4-methoxy-phenyl)-ethyl]-3,7,12,17-tetramethyl-22,24-dihydro-porphin-2-yl}-propionic acid methyl ester (140411-01-4)

Guidance literature:

Yield given. Multistep reaction. Further byproducts given;

upstream raw materials:

methanol

hematoporphyrin

methoxybenzene

protoporphyrin IX dimethyl ester

Downstream raw materials:

C₅₈H₆₆N₄O₁₀S₂

C₅₈H₆₈N₆O₁₀

C₆₀H₇₀N₄O₁₀

3-{(1Z,4Z,9Z,15Z)-7,12-Bis-(1-methoxy-ethyl)-3,8,13,17-tetramethyl-18-[2-(2,4,5-trimethyl-3,6-dioxo-cyclohexa-1,4-dienylmethoxycarbonyl)-ethyl]-porphyrin-2-yl}-propionic acid 2,4,5-trimethyl-3,6-dioxo-cyclohexa-1,4-dienylmethyl ester

Refernces

• 1、 Byrne, Christopher J.,Ward, A. David. "A FACILE PORPHYRIN ESTERIFICATION / ETHERIFICATION PROCEDURE". . p. 1421 - 1424. Retrieved 2007/10/02.