5-Pyrimidineethanol

Base Information

• Chemical Name: 5-Pyrimidineethanol
• CAS No.: 875251-47-1
• Molecular Formula: C6H8N2O
• Molecular Weight: 124.142
• Hs Code.: 2933599090
• Mol file: 875251-47-1.mol

Synonyms:2-(Pyrimidin-5-yl)ethanol;

Chemical Property of 5-Pyrimidineethanol

Chemical Property:

• Vapor Pressure: 0.011mmHg at 25°C
• Refractive Index: 1.544
• Boiling Point: 251.756 °C at 760 mmHg
• PKA: 14.50±0.10(Predicted)
• Flash Point: 106.058 °C
• PSA: 46.01000
• Density: 1.169 g/cm³
• LogP: 0.01140
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-(pyrimidin-5-yl)ethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Pyrimidineethanol

There total 4 articles about 5-Pyrimidineethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.5%

2-(4,6-dichloropyrimidin-5-yl)ethanol (853680-74-7) → 2-(pyrimidin-5-yl)ethan-1-ol (875251-47-1)

Guidance literature:

With palladium on activated charcoal; hydrogen; magnesium oxide; In methanol; at 20 ℃; for 16h;

Reference yield: 30.0%

ethyl 2-(pyrimidin-5-yl)acetate (6214-48-8) → 2-(pyrimidin-5-yl)ethan-1-ol (875251-47-1)

Guidance literature:

With sodium tetrahydroborate; ethanol; at 0 - 20 ℃; Inert atmosphere;

Reference yield:

2-(4,6-dichloropyrimidin-5-yl)acetaldehyde (16019-33-3) → 2-(pyrimidin-5-yl)ethan-1-ol (875251-47-1)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol; sodium tetrahydroborate / 2 h / 0 - 20 °C

2: hydrogen; magnesium oxide; palladium on activated charcoal / methanol / 16 h / 20 °C

With methanol; sodium tetrahydroborate; palladium on activated charcoal; hydrogen; magnesium oxide; In methanol;

upstream raw materials:

ethyl 2-(pyrimidin-5-yl)acetate

2-(4,6-dichloropyrimidin-5-yl)ethanol

2-(4,6-dichloropyrimidin-5-yl)acetaldehyde

Refernces

• 1、 -. "IMIDAZOTRIAZINONE COMPOUNDS". Paragraph 0712; 0713; 0714. . Retrieved 2013/10/08.