1-(3-Methoxypropyl)-4-piperidinamine

Base Information

• Chemical Name: 1-(3-Methoxypropyl)-4-piperidinamine
• CAS No.: 179474-79-4
• Molecular Formula: C9H20N2O
• Molecular Weight: 172.271
• Hs Code.: 2933399090
• European Community (EC) Number: 431-950-8
• DSSTox Substance ID: DTXSID80477332
• Wikidata: Q72518157
• Mol file: 179474-79-4.mol

Synonyms:179474-79-4;1-(3-methoxypropyl)piperidin-4-amine;1-(3-Methoxypropyl)-4-piperidinamine;4-AMINO-1-(3-METHOXYPROPYL)PIPERIDINE;4-Piperidinamine, 1-(3-methoxypropyl)-;MFCD11104531;EC 431-950-8;SCHEMBL6176615;DTXSID80477332;HIXAJGFVNMKLML-UHFFFAOYSA-N;BCP13150;1-(3methoxypropyl)-4-piperidinamine;4-Piperidinamine,1-(3-methoxypropyl);AKOS009330878;AM85328;DS-3987;PB22465;AC-28384;SY033501;CS-0052882;FT-0763616;NS00077753;EN300-65687;J-503161;Z382722326

Chemical Property of 1-(3-Methoxypropyl)-4-piperidinamine

Chemical Property:

• Boiling Point: 249℃
• PKA: 10.49±0.20(Predicted)
• Flash Point: 105℃
• PSA: 38.49000
• Density: 0.946
• LogP: 1.08420
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: 0.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 172.157563266
• Heavy Atom Count: 12
• Complexity: 111

Purity/Quality:

99.9% ^*data from raw suppliers

4-Amino-1-(3-methoxypropyl)piperidine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COCCCN1CCC(CC1)N
• Uses: 1-(3-Methoxypropyl)-4-piperidinamine is a useful synthetic intermediate in the synthesis of Prucalopride Succinate (P838950); a selective 5-HT4 receptor agonist used effective for chronic constipation, but is not currently approved in the U.S. Prucalopride is approved for the treatment of chronic constipation in Europe.

Technology Process of 1-(3-Methoxypropyl)-4-piperidinamine

There total 5 articles about 1-(3-Methoxypropyl)-4-piperidinamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

1-[3-(methyloxy)propyl]-4-piperidinecarboxamide (519147-89-8) → 4-amino-1-(3-methoxypropyl)piperidine (179474-79-4)

Guidance literature:

With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; potassium hydroxide; In water; acetonitrile; at 5 - 25 ℃; for 13h;

Reference yield: 81.0%

C22H28N2O → 4-amino-1-(3-methoxypropyl)piperidine (179474-79-4)

Guidance literature:

With hydrogenchloride; In water; at 0 - 20 ℃; pH=1 - 2;

Reference yield:

ethyl 1-(3-methoxy-propyl)-piperidin-4-carboxylate (1249604-45-2) → 4-amino-1-(3-methoxypropyl)piperidine (179474-79-4)

Guidance literature:

Multi-step reaction with 2 steps

1: ammonia / methanol / 60 °C

2: potassium hydroxide; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / water; acetonitrile / 13 h / 5 - 25 °C

With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; ammonia; potassium hydroxide; In methanol; water; acetonitrile;

upstream raw materials:

ethyl 1-(3-methoxy-propyl)-piperidin-4-carboxylate

1-[3-(methyloxy)propyl]-4-piperidinecarboxamide

4-aminopiperidine

Downstream raw materials:

prucalopride succinate

prucalopride

Refernces

• 1、 -. "A process for the preparation of intermediate the Pu card must benefit new process (by machine translation)". . . Retrieved 2017/07/20.