6-BROMO-4-CHLORO-3-NITROQUINOLINE

Base Information

• Chemical Name: 6-BROMO-4-CHLORO-3-NITROQUINOLINE
• CAS No.: 723281-72-9
• Molecular Formula: C9H4BrClN2O2
• Molecular Weight: 287.5
• Hs Code.: 2933499090
• Mol file: 723281-72-9.mol

Synonyms:6-BROMO-4-CHLORO-3-NITROQUINOLINE;

Chemical Property of 6-BROMO-4-CHLORO-3-NITROQUINOLINE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.711
• Boiling Point: 387.626 °C at 760 mmHg
• PKA: -1.08±0.27(Predicted)
• Flash Point: 188.23 °C
• PSA: 58.71000
• Density: 1.834 g/cm³
• LogP: 4.08210
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

99% ^*data from raw suppliers

6-Bromo-4-chloro-3-nitroquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-BROMO-4-CHLORO-3-NITROQUINOLINE

There total 11 articles about 6-BROMO-4-CHLORO-3-NITROQUINOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

6-bromo-3-nitroquinolin-4-ol (853908-50-6) → 6-bromo-4-chloro-3-nitroquinoline (723281-72-9)

Guidance literature:

With trichlorophosphate; for 0.75h; Reflux;

Reference yield: 53.0%

C10H6BrNO3 → 6-bromo-4-chloro-3-nitroquinoline (723281-72-9)

Guidance literature:

With trichlorophosphate; at 120 ℃; for 1h;

Reference yield:

6-bromoquinolin-4-ol (145369-94-4) → 6-bromo-4-chloro-3-nitroquinoline (723281-72-9)

Guidance literature:

Multi-step reaction with 2 steps

1: nitric acid / propionic acid / 2 h / 125 °C

2: trichlorophosphate; triethylamine / 1.5 h / Reflux

With nitric acid; triethylamine; trichlorophosphate; In propionic acid;

DOI:10.1016/j.bmcl.2013.12.095

upstream raw materials:

6-bromo-3-nitroquinolin-4-ol

(E)-5-bromo-2-((2-nitrovinyl)amino)benzoic acid

5-bromo-2-((2-nitroethenyl)amino)benzoic acid

5-Bromo-2-aminobenzoic acid

Downstream raw materials:

[4-(6-bromo-3-nitro-quinolin-4-ylamino)phenyl]acetonitrile

2-[4-(3-amino-6-bromo-quinolin-4-ylamino)-phenyl]-2-methyl-propionitrile

2-(4-(8-bromo-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile

2-(4-(8-bromo-2-oxo-3-(4-(trifluoromethoxy)phenylsulfonyl)-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile

Refernces

• 1、 -. "Nitrogen-containing heterocyclic compound and medicinal composition and application thereof". Paragraph 0295-0300. . Retrieved 2021/05/29.
• 2、 -. "Compound serving as Hippo signal channel inhibitor". Paragraph 0087-0089. . Retrieved 2020/12/31.