7-Propyl-3-(trifluoromethyl)benzo[d]isoxazol-6-ol

Base Information

• Chemical Name: 7-Propyl-3-(trifluoromethyl)benzo[d]isoxazol-6-ol
• CAS No.: 194608-88-3
• Molecular Formula: C11H10F3NO2
• Molecular Weight: 245.1978
• Mol file: 194608-88-3.mol

Synonyms:Trifluoromethyl-7-propyl-6-hydroxybenzisoxazole;

Chemical Property of 7-Propyl-3-(trifluoromethyl)benzo[d]isoxazol-6-ol

Chemical Property:

• Boiling Point: 323.5 °C at 760 mmHg
• Flash Point: 149.4 °C
• PSA: 46.26000
• Density: 1.355 g/cm³
• LogP: 3.50470
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

7-Propyl-3-(trifluoromethyl)benzo[d]isoxazol-6-ol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-Propyl-3-(trifluoromethyl)benzo[d]isoxazol-6-ol

There total 11 articles about 7-Propyl-3-(trifluoromethyl)benzo[d]isoxazol-6-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4-dihydroxy-3-propyl-1',1',1'-trifluoroacetophenone (65239-69-2) → 7-dipropyl-6-hydroxy-3-trifluoromethyl-1,2-benzisoxazole (194608-88-3)

Guidance literature:

Multi-step reaction with 3 steps

1: hydroxylamine hydrochloride; NaOAc / methanol / Heating

2: 20 °C

3: pyridine; Et₃N / 3 h / 112 °C

With pyridine; hydroxylamine hydrochloride; sodium acetate; triethylamine; In methanol;

DOI:10.1021/jm048993p

Reference yield:

7-allyl-3-trifluoromethyl-benzo[d]isoxazol-6-ol → 7-dipropyl-6-hydroxy-3-trifluoromethyl-1,2-benzisoxazole (194608-88-3)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate; for 2h; under 2280 Torr;

DOI:10.1021/jm0506930

Reference yield:

C13H14F3NO4 → 7-dipropyl-6-hydroxy-3-trifluoromethyl-1,2-benzisoxazole (194608-88-3)

Guidance literature:

With pyridine; Heating;

DOI:10.1016/S0960-894X(03)00702-9

upstream raw materials:

3-trifluoromethyl-benzo[d]isoxazol-6-ol

1-(2,4-dihydroxy-phenyl)-2,2,2-trifluoro-ethanone oxime

2,4-dihydroxy-1’,1’,1’-trifluoroacetophenone

recorcinol

Downstream raw materials:

{3-chloro-4-[3-(7-propyl-3-trifluoromethyl-benzo[d]isoxazol-6-yloxy)-propylsulfanyl]-phenyl}-acetic acid methyl ester

Refernces

• 1、 -. "Therapeutic compounds for treating dyslipidemic conditions". Page/Page column 15. . Retrieved 2008/06/13.
• 2、 Mahindroo, Neeraj,Huang, Chien-Fu,Peng, Yi-Huei,Wang, Chiung-Chiu,Liao, Chun-Chen,Lien, Tzu-Wen,Chittimalla, Santhosh Kumar,Huang, Wei-Jan,Chai, Chia-Hua,Prakash, Ekambaranellore,Chen, Ching-Ping,Hsu, Tsu-An,Peng, Cheng-Hung,Lu, I-Lin,Lee, Ling-Hui,Chang, Yi-Wei,Chen, Wei-Cheng,Chou, Yu-Chen,Chen, Chiung-Tong,Goparaju, Chandra M. V.,Chen, Yuan-Shou,Lan, Shih-Jung,Yu, Ming-Chen,Chen, Xin,Chao, Yu-Sheng,Wu, Su-Ying,Hsieh, Hsing-Pang. "Novel indole-based peroxisome proliferator-activated receptor agonists: Design, SAR, structural biology, and biological activities". . p. 8194 - 8208. Retrieved 2007/10/03.