Methyl 3-formyl-4-indazolecarboxylate

Base Information

• Chemical Name: Methyl 3-formyl-4-indazolecarboxylate
• CAS No.: 433728-79-1
• Molecular Formula: C10H8N2O3
• Molecular Weight: 204.185
• Hs Code.: 2933990090
• Mol file: 433728-79-1.mol

Synonyms:Methyl 3-formyl-1H-indazole-4-carboxylate;

Chemical Property of Methyl 3-formyl-4-indazolecarboxylate

Chemical Property:

• Vapor Pressure: 3.06E-07mmHg at 25°C
• Refractive Index: 1.687
• Boiling Point: 419.4 °C at 760 mmHg
• Flash Point: 207.4 °C
• PSA: 72.05000
• Density: 1.411 g/cm³
• LogP: 1.16200

Purity/Quality:

99% ^*data from raw suppliers

3-Formyl-4-indazolecarboxylicAcidmethylester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 3-formyl-4-indazolecarboxylate

There total 1 articles about Methyl 3-formyl-4-indazolecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

methyl 1H-indole-4-carboxylate (39830-66-5) → methyl 3-formyl-1H-indazole-4-carboxylate (433728-79-1)

Guidance literature:

With hydrogenchloride; sodium nitrite; In water; at 20 ℃;

Reference yield: 100.0%

methyl 3-formyl-1H-indazole-4-carboxylate (433728-79-1) + 4-aminomethylquinuclidine (67496-78-0) → methyl 3-((quinuclidin-4-ylmethylamino)methyl)-1H-indazole-4-carboxylate (1262420-77-8)

Guidance literature:

methyl 3-formyl-1H-indazole-4-carboxylate; 4-aminomethylquinuclidine; With acetic acid; In 1,4-dioxane; at 60 ℃; for 2h;

With sodium tris(acetoxy)borohydride; In 1,4-dioxane; at 20 ℃; for 4h;

Reference yield: 53.0%

methyl 3-formyl-1H-indazole-4-carboxylate (433728-79-1) + p-Methoxybenzyl bromide (2746-25-0) → methyl 3-formyl-2-(4-methoxybenzyl)-2H-indazole-4-carboxylate (1262420-96-1) + methyl 3-formyl-1-(4-methoxybenzyl)-1H-indazole-4-carboxylate (1262420-83-6)

Guidance literature:

methyl 3-formyl-1H-indazole-4-carboxylate; With caesium carbonate; In N,N-dimethyl-formamide; at 0 ℃; Inert atmosphere;

p-Methoxybenzyl bromide; With sodium iodide; at 20 ℃;

upstream raw materials:

methyl 1H-indole-4-carboxylate

Downstream raw materials:

methyl 1-benzyl-3-formyl-1H-indazole-4-carboxylate

methyl 3-formyl-1-(4-fluorophenyl)-1H-indazole-4-carboxylate

methyl 3-formyl-2-(4-methoxybenzyl)-2H-indazole-4-carboxylate

methyl 3-formyl-1-(4-methoxybenzyl)-1H-indazole-4-carboxylate

Refernces