5-(Bromomethyl)-2-methylpyrimidin-4-amine hydrobromide

Base Information

• Chemical Name: 5-(Bromomethyl)-2-methylpyrimidin-4-amine hydrobromide
• CAS No.: 2908-71-6
• Molecular Formula: C6H8BrN3·HBr
• Molecular Weight: 282.966
• Hs Code.: 2933599090
• DSSTox Substance ID: DTXSID90500963
• NSC Number: 13144
• Mol file: 2908-71-6.mol

Synonyms:2908-71-6;5-(Bromomethyl)-2-methylpyrimidin-4-amine hydrobromide;4-AMINO-5-(BROMOMETHYL)-2-METHYLPYRIMIDINE HYDROBROMIDE;5-(bromomethyl)-2-methylpyrimidin-4-amine;hydrobromide;4-Pyrimidinamine, 5-(bromomethyl)-2-methyl-, monohydrobromide;4-Pyrimidinamine, 5-(bromomethyl)-2-methyl-, hydrobromide (1:1);C6H9Br2N3;SCHEMBL11751013;DTXSID90500963;NZXPJPYPDFCVTK-UHFFFAOYSA-N;AMY15880;CAA90871;NSC13144;MFCD05149311;NSC-13144;AKOS015833735;SB60731;DS-15599;CS-0089026;5-(Bromomethyl)-2-methylpyrimidin-4-amine HBr;D74791;2-Methyl-4-amino-5-brommethyl-pyrimidinhydrobromid;EN300-23609700;5-(Bromomethyl)-2-methylpyrimidin-4-aminehydrobromide;4-amino-2-methyl-5-pyrimidinyl-methyl bromide hydrobromide;5-(Bromomethyl)-2-methylpyrimidin-4-amine--hydrogen bromide (1/1)

Chemical Property of 5-(Bromomethyl)-2-methylpyrimidin-4-amine hydrobromide

Chemical Property:

• Melting Point: 192-193 °C
• Boiling Point: 339.9 °C at 760 mmHg
• Flash Point: 159.4 °C
• PSA: 51.80000
• LogP: 2.80140
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 282.91427
• Heavy Atom Count: 11
• Complexity: 109

Purity/Quality:

NLT 98% ^*data from raw suppliers

4-AMINO-5-(BROMOMETHYL)-2-METHYLPYRIMIDINE HYDROBROMIDE 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=NC=C(C(=N1)N)CBr.Br
• Uses: A pyrimidine derivative as G protein-coupled receptor kinase (GRK) inhibitor.

Technology Process of 5-(Bromomethyl)-2-methylpyrimidin-4-amine hydrobromide

There total 5 articles about 5-(Bromomethyl)-2-methylpyrimidin-4-amine hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

4-amino-5-methoxymethyl-2-methylpyrimidine (769-82-4) → 4-amino-5-bromomethyl-2-methylpyrimidine hydrobromide (2908-71-6)

Guidance literature:

With hydrogen bromide; In acetic acid; at 100 ℃; Temperature; Solvent;

Reference yield: 81.0%

5-ethoxymethyl-2-methyl-pyrimidin-4-ylamine (73-66-5) → 4-amino-5-bromomethyl-2-methylpyrimidine hydrobromide (2908-71-6)

Guidance literature:

With hydrogen bromide; acetic acid; at 20 - 100 ℃; for 2h;

Reference yield:

2-methyl-5-ethoxymethyl-6-hydroxypyrimidine → 4-amino-5-bromomethyl-2-methylpyrimidine hydrobromide (2908-71-6)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine; trichlorophosphate / 3 h / 78 °C

2: ammonia / methanol / 4.5 h / 140 °C / Autoclave

3: acetic acid; hydrogen bromide / 2 h / 20 - 100 °C

With ammonia; hydrogen bromide; acetic acid; triethylamine; trichlorophosphate; In methanol;

upstream raw materials:

4-amino-5-methoxymethyl-2-methylpyrimidine

5-ethoxymethyl-2-methyl-pyrimidin-4-ylamine

2-methyl-5-ethoxymethyl-6-chloropyrimidine

Downstream raw materials:

thiochrome

5-ethoxycarbonyl-3-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-4-methyl-thiazolium; chloride-hydrochloride

N-(2-methyl-4-amino-5-pyrimidinyl)methylaniline

3-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-5-phenyl-[1,3,4]thiadiazolium; bromide hydrobromide

Refernces

• 1、 -. "Synthesizing method for 4-amino-2-methyl-5-(brooethyl) pyrimidine hydrobromide". Paragraph 0031; 0032-0086; 0091; 0096; 0101. . Retrieved 2018/03/01.