3-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-5-phenyl-[1,3,4]thiadiazolium; bromide hydrobromide

Base Information

• Chemical Name: 3-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-5-phenyl-[1,3,4]thiadiazolium; bromide hydrobromide
• CAS No.: 27497-92-3
• Molecular Formula: BrH*Br*C₁₄H₁₄N₅S
• Molecular Weight: 445.181
• Mol file: 27497-92-3.mol

Synonyms:

Chemical Property of 3-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-5-phenyl-[1,3,4]thiadiazolium; bromide hydrobromide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-5-phenyl-[1,3,4]thiadiazolium; bromide hydrobromide

There total 1 articles about 3-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-5-phenyl-[1,3,4]thiadiazolium; bromide hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phenyl-1,3,4-thiadiazole (4291-14-9) + 4-amino-5-bromomethyl-2-methylpyrimidine hydrobromide (2908-71-6) → 3-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-5-phenyl-[1,3,4]thiadiazolium; bromide hydrobromide (27497-92-3)

Guidance literature:

In N,N-dimethyl-formamide; at 65 ℃;

Reference yield:

dimethyl benzoylphosphonate (18106-71-3) + 3-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-5-phenyl-[1,3,4]thiadiazolium; bromide hydrobromide (27497-92-3) → phosphoric acid dimethyl ester (6-methyl-2-phenyl-4,9-dihydro-pyrimido[4,5-d][1,3,4]thiadiazolo[3,2-a]pyrimidin-3a-yl)-phenyl-methyl ester (27374-33-0)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at -60 - -50 ℃;

Reference yield:

3-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-5-phenyl-[1,3,4]thiadiazolium; bromide hydrobromide (27497-92-3) + dimethyl acetylphosphonate (17674-28-1) → phosphoric acid dimethyl ester 1-(6-methyl-2-phenyl-4,9-dihydro-pyrimido[4,5-d][1,3,4]thiadiazolo[3,2-a]pyrimidin-3a-yl)-ethyl ester (27512-93-2)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at -60 - -50 ℃;

upstream raw materials:

phenyl-1,3,4-thiadiazole

4-amino-5-bromomethyl-2-methylpyrimidine hydrobromide

Downstream raw materials:

phosphoric acid dimethyl ester (6-methyl-2-phenyl-4,9-dihydro-pyrimido[4,5-d][1,3,4]thiadiazolo[3,2-a]pyrimidin-3a-yl)-phenyl-methyl ester

6-methyl-2-phenyl-4,9-dihydro-3aH-pyrimido[4,5-d][1,3,4]thiadiazolo[3,2-a]pyrimidine

phosphoric acid dimethyl ester 1-(6-methyl-2-phenyl-4,9-dihydro-pyrimido[4,5-d][1,3,4]thiadiazolo[3,2-a]pyrimidin-3a-yl)-ethyl ester

4-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-6-methyl-2-phenyl-4H-[1,3,4]thiadiazin-5-one